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首页> 外文期刊>Advances in enzyme regulation >Caveolin-1 inhibits anoikis and promotes survival signaling in cancer cells
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Caveolin-1 inhibits anoikis and promotes survival signaling in cancer cells

机译：Caveolin-1抑制凋亡并促进癌细胞中的生存信号

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摘要

Caveolae have garnered a great deal of attention during the last decade, as they appear to mediate multiple cellular functions, including clathrin-independent endocytosis, cholesterol efflux and regulation of intracellular signaling pathways (Razani et al., 2002; Parton, 2003). Defined as non-clathrin-coated, flask-shaped invaginations of the plasma membrane, caveolae sometime appear also as juxtamembrane vesicles that occur singly or in clusters and are fairly uniform in size (50-100 nm in diameter) (Anderson, 1998). Caveolae are related to membrane microdomains called lipid rafts, with which they share an unusual lipid composition that differs from that of bulk cellular membranes in being enriched with cholesterol and sphingolipids. Therefore, caveolae may be considered a subset of lipid rafts. Because of their unique lipid composition, membranes of lipid rafts and caveolae exhibit a liquid-ordered phase behavior that is intermediate in properties between the liquid crystalline phase of bulk cellularmembranes and the gel phase of simple lipid bilayers composed of one or more saturated phospholipid species (Brown and London, 1997). The liquid-ordered phase of rafts and caveolar membranes turned out to be quite useful, as it confers upon the membranes an insolubility in certain non-ionic detergents at 4degC.
机译：在过去的十年中，海绵体病引起了广泛的关注，因为它们似乎介导多种细胞功能，包括网格蛋白非依赖性内吞作用，胆固醇外排和细胞内信号通路的调节（Razani等人，2002; Parton，2003）。小窝被定义为非clathrin包被的质膜的烧瓶状内陷，有时也以近膜状囊泡的形式出现，单个或成簇出现，大小相当均匀（直径50-100 nm）（Anderson，1998）。小窝与膜微区有关，称为脂质筏，它们具有不寻常的脂质组成，与大量细胞膜的脂质组成不同，富含胆固醇和鞘脂。因此，小窝可被认为是脂质筏的子集。由于其独特的脂质组成，脂质筏和小窝的膜表现出液相有序的行为，其性质介于大分子细胞膜的液晶相与由一种或多种饱和磷脂物质组成的简单脂质双层的凝胶相之间的性质之间（布朗和伦敦，1997年）。事实证明，筏板和海绵膜的液相排列相非常有用，因为它使膜在某些非离子型去污剂中在4℃下不溶。

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