Nuclear inositide signaling: An appraisal of phospholipase C beta1 behavior in myelodysplastic and leukemia cells

Lucio Cocco; Matilde Y. Follo; Irene Faenza Alberto Bavelloni; Anna Maria Billi

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Nuclear inositide signaling: An appraisal of phospholipase C beta1 behavior in myelodysplastic and leukemia cells

机译：核苷信号：骨髓增生异常和白血病细胞中磷脂酶C beta1行为的评估

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Phospholipids are key regulators of a large number of cellular functions and do not act merely as structural components of biological membranes. Among phospholipids, polyphosphoinositides are key players in a number of signaling pathways. Inositol phospholipids are quantitatively minor constituents of cell membranes. Indeed, phosphatidylinositol (PI) typically comprises approximately 10% of total membrane lipid. This hints at the fact that inositol lipids are likely to play a major functional role.

机译：磷脂是许多细胞功能的关键调节剂，而不仅仅是生物膜的结构成分。在磷脂中，多磷酸肌醇是许多信号传导途径中的关键参与者。肌醇磷脂在数量上是细胞膜的次要组成部分。实际上，磷脂酰肌醇（PI）通常占总膜脂质的约10％。这暗示了肌醇脂质可能起主要功能作用的事实。

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来源
《Advances in enzyme regulation》 |2007年第0期|共8页
作者
Lucio Cocco; Matilde Y. Follo; Irene Faenza Alberto Bavelloni; Anna Maria Billi;
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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
Phospholipids; Nuclear; behavioral aspects; phospholipase C beta1; 磷脂类;

机译：Phospholipids;Nuclear;behavioral aspects;phospholipase C beta1;磷脂类;

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1. Nuclear inositide signaling: An appraisal of phospholipase C beta1 behavior in myelodysplastic and leukemia cells [J] . Lucio Cocco, Matilde Y. Follo, Irene Faenza Alberto Bavelloni, Advances in enzyme regulation . 2007,第0期

机译：核苷信号：骨髓增生异常和白血病细胞中磷脂酶C beta1行为的评估
2. Differential activation of nuclear inositide-dependent signalling pathways during erythropoiesis and myelopoiesis induced by lenalidomide and azacitidine in myelodysplastic syndromes (MDS) [J] . Sara Mongiorgi, Matilde Y. Follo, Cristina Clissa, Italian Journal of Anatomy and Embryology . 2015,第1期

机译：来那度胺和阿扎胞苷在骨髓增生异常综合症（MDS）引起的红细胞生成和骨髓生成过程中核肌苷依赖性信号通路的差异激活
3. Strategic Role of Nuclear Inositide Signalling in Myelodysplastic Syndromes Therapy [J] . Manzoli Lucia, Mongiorgi Sara, Clissa Cristina, Mini reviews in medicinal chemistry . 2014,第11期

机译：核苷信号在骨髓增生异常综合征治疗中的战略作用
4. Nuclear phospholipase C β1, regulationof the cell cycle and progression of acutemyeloid leukemia [C] . Lucio Cocco, Lucia Manzoli, Giandomenico Palka, International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2005

机译：核磷脂酶Cβ1，调节细胞周期和急性髓细胞白血病的进展
5. Analysis of amino acid signals within the human T cell leukemia virus type I transactivator protein Tax that control nuclear export, cytoplasmic intracellular localization, and secretion. [D] . Alefantis, Timothy Gerard. 2003

机译：分析人T细胞白血病病毒I型反式激活蛋白Tax中的氨基酸信号，该蛋白控制核的输出，胞质的细胞内定位和分泌。
6. Nuclear Inositides and Inositide-Dependent Signaling Pathways in Myelodysplastic Syndromes [O] . Jie Xian, Eric Owusu Obeng, Stefano Ratti, 2020

机译：骨髓增生异常综合征中的核肌苷和肌苷依赖性信号通路。
7. Deletion of the inositide-specific phospholipase c beta1 gene is a rare event in myelodysplastic syndrome and thus of limited value to predict leukemic progression [O] . Verburgh, Estelle, Verhoef, Gregor, Vandenberghe, Peter, 2005

机译：肌苷特异性磷脂酶c beta1基因的删除是骨髓增生异常综合症中的罕见事件，因此在预测白血病进展方面价值有限

Nuclear inositide signaling: An appraisal of phospholipase C beta1 behavior in myelodysplastic and leukemia cells

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