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首页> 外文期刊>Advances in Experimental Medicine and Biology >Does human lactoferrin in the milk of transgenic mice deliver iron to suckling neonates?
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Does human lactoferrin in the milk of transgenic mice deliver iron to suckling neonates?

机译：转基因小鼠乳汁中的人乳铁蛋白是否能将铁传递给哺乳的新生儿？

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摘要

Lactoferrin is an iron-binding glycoprotein abundantly present in human milk, and has been postulated both to increase and to decrease intestinal iron absorption. To examine this problem, the interaction of milk iron with pup hemoglobin was studied in controls and in transgenic mice overexpressing human lactoferrin in their milk (2 lines expressing 12 mg/mL and 4 mg/mL, respectively). At day 14 of gestation, pregnant mice were switched from a diet of commercial chow containing iron at 300 mg/kg to diets containing 5, 15, or 50mg iron/kg; controls continued on chow. Nontransgenic pups were cross-fostered to transgenic dams to ensure that any results found in the pups were the effect of milk components. The hemoglobin level in the blood of 10-day-old suckling neonates was measured and calculated as total hemoglobin per pup. The total hemoglobin levels were lower in the pups receiving milk high in human lactoferrin, but the difference reached significance (P < 0.02) only at the highest level of dietary iron. Our findings do not support the hypothesis that lactoferrin functions as an intestinal iron scavenger, at least at high doses.
机译：乳铁蛋白是一种富含铁的糖蛋白，存在于母乳中，被认为既增加又减少肠中铁的吸收。为了检验这个问题，在对照和过表达牛奶中人乳铁蛋白的转基因小鼠（分别表达12 mg / mL和4 mg / mL的2个品系）中研究了乳铁与幼犬血红蛋白的相互作用。在妊娠的第14天，将妊娠小鼠从含300 mg / kg铁的商业食物饮食改为含5、15或50mg铁/ kg的饮食;控制继续进行。将非转基因幼崽交叉培育到转基因坝上，以确保在幼崽中发现的任何结果都是牛奶成分的影响。测量10日龄哺乳新生儿血液中的血红蛋白水平，并将其计算为每只幼犬的总血红蛋白。在人乳铁蛋白含量高的牛奶中，幼犬的总血红蛋白水平较低，但仅在最高铁水平下，差异才达到显着水平（P <0.02）。我们的发现不支持乳铁蛋白至少在高剂量时起肠铁清除剂作用的假说。

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