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首页> 外文期刊>International Journal of Medicinal Mushrooms >Nephroprotective and Antioxidant Effects of King Tuber Oyster Medicinal Mushroom, Pleurotus tuber-regium (Agaricomycetes), on Carbon Tetrachloride-Induced Nephrotoxicity in Male Sprague Dawley Rats
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Nephroprotective and Antioxidant Effects of King Tuber Oyster Medicinal Mushroom, Pleurotus tuber-regium (Agaricomycetes), on Carbon Tetrachloride-Induced Nephrotoxicity in Male Sprague Dawley Rats

机译：King Tuber Oyster医药蘑菇，胸膜肺炎植物（伞菌菌根），在雄性Sprague Dawley大鼠中的四氯化物诱导的肾毒性上肾外牡蛎药用蘑菇

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Chronic kidney disease is a health burden worldwide but particularly in sub-Saharan Africa, with dwindling resources as a result of poor commodity export, devaluation of currencies, and corruption that had decreased the average family income and substantially increased the number of persons living on less than $1.90/day. Natural products are part of the healthcare delivery system in that part of the world. This study was conducted to evaluate the protective effects of Pleurotus tuber-regium on the kidneys of rats treated with carbon tetrachloride (CCl4) for 13 weeks. Sixty rats were divided into 6 groups, with 10 animals in each group. Group I (control) received olive oil (3 mL/kg) intraperitoneally twice weekly and were given feed and water ad libitum. Group II received CCl4 (3 mL/kg, 30% in olive oil) twice weekly. Groups III, IV, and V received 100, 200, and 500 mg/kg wild edible P. tuber-regium (33.3% in feed) daily, respectively, in addition to 3 mL/kg CCl4 twice weekly. Group VI received 500 mg/kg P. tuber-regium (33.3% in feed) daily. At the end of 13 weeks, the animals were sacrificed and kidney weights recorded. Serum concentrations of creatinine, urea, and fasting blood glucose were assayed. Malondialdehyde, ascorbic acid, alpha-tocopherol, superoxide dismutase, catalase, total glutathione, and peroxidase were measured in kidney homogenate. The kidneys were also histologically examined. Administration of CCl4 to rats significantly (P & 0.05) increased the absolute and relative kidney weights from 0.93 +/- 0.04 and 0.38 +/- 0.02 g in the control group to 1.30 +/- 0.04 and 0.58 +/- 0.02 g in the treated groups (Groups III, IV, and V), respectively. CCl4 administration increased the concentrations of creatinine, urea, fasting blood glucose, and malondialdehyde from 0.53 +/- 0.05 mg/dL, 17.0 +/- 1.10 mg/dL, 72 +/- 2.80 mg/dL, and 1.40 +/- 0.32 mu mol/L in the control group to 0.84 +/- 0.03 mg/dL, 43.0 +/- 6.90 mg/dL, 77 +/- 2.2 mg/dL, and 14.0 +/- 3.5 mu mol/L in the treated groups, respectively. The concentrations of ascorbic acid, alpha-tocopherol, superoxide dismutase, catalase, total glutathione, and peroxidase decreased significantly (P & 0.05) from 0.41 +/- 0.02 mg/dL, 5.15 +/- 0.21 mu g/mL, 8.49 +/- 0.38 units/mL, 75.20 +/- 4.57 mU/mL, 1.62 +/- 0.03 mu g/mL, and 9.74 +/- 0.40 mU/mL, in the control group to 0.24 +/- 0.03 mg/dL, 1.80 +/- 0.11 mu g/mL, 2.78 +/- 0.30 units/mL, 31.9 +/- 5.87 mU/mL, 0.36 +/- 0.04 mu g/mL, and 3.84 +/- 0.22 mU/mL in the treated groups, respectively. Photomicrographs showed that P. tuber-regium prevented the fibrosis and tubular and Bowman capsule distortions observed in the CCl4-only group. P. tuber-regium is effective in protecting the kidneys against CCl4-induced damage.
机译：慢性肾病是全世界健康负担，但特别是在撒哈拉以南非洲，由于商品出口不佳，货币贬值和腐败，普通家庭收入的损失，并大大增加了生活的人数超过1.90 /天。天然产品是世界上的医疗保健交付系统的一部分。进行该研究以评估Pleurotus Tuber-Regium对用四氯化碳（CCl4）处理的大鼠肾脏的保护作用13周。将六十只大鼠分成6组，每组10只动物。 I族（对照）每周腹膜内腹膜内腹膜内的橄榄油（3ml / kg），并给予饲料和水广告。 II组每周接受CCL4（3ml / kg，橄榄油30％）。除了3ml / kg CCl4每周两次，分别收到100,200和500mg / kg野生食用菌，分别每日收到100,200和500mg / kg野生食用菌（33.3％）。 VI组每天收到500 mg / kg p.菌根（饲料33.3％）。在13周结束时，处死动物并记录肾脏重量。测定血清肌酐，尿素和空腹血糖的浓度。在肾均质中测量丙二醛，抗坏血酸，α-生育酚，超氧化物歧化酶，过氧化氢酶，总谷胱甘肽和过氧化物酶。肾脏也被组织学检查。将CCL4施用于大鼠的大鼠（P＆amp; 0.05），对照组中的0.93 +/- 0.04和0.38 +/- 0.02g增加至1.30 +/- 0.04和0.58 +/- 0.02的绝对和相对肾脏重量增加G分别在治疗组（III组，IV组和V）中。 CCL4给药增加了0.53 +/- 0.05mg / dl，17.0 +/- 1.10mg / dl，72 +/- 2.80mg / dl，1.40 +/- 0.32的肌酐，尿素，空腹血糖和丙二醛的浓度增加在对照组中mu mol / l至0.84 +/- 0.03 mg / dl，43.0 +/- 6.90 mg / dl，77 +/- 2.2 mg / dl，治疗组中的14.0 +/- 3.5 mm mol / l ， 分别。抗坏血酸，α-生育酚，超氧化物歧化酶，过氧化氢酶，总谷胱甘肽和过氧化物酶的浓度显着（P＆amp; 0.05）从0.41 +/- 0.02mg / dl，5.15 +/-0.21μg/ ml， 18.49 +/- 0.38单位/ ml，75.20 +/- 4.57 mu / ml，1.62 +/-0.03μmg/ ml和9.74 +/- 0.40 mu / ml，在对照组中，0.24 +/- 0.03 mg / DL，1.80 +/-0.11μg/ ml，2.78 +/- 0.30单位/ ml，31.9 +/- 5.87 mu / ml，0.36 +/- 0.04 mu g / ml，3.84 +/- 0.22 mu / ml治疗组分别。显微照片显示P.Tuber-Regium预防CCL4群中观察到纤维化和管状和弓贩胶囊畸变。 P. Tuber-Regium有效地保护肾脏免受CCL4诱导的损伤。

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