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首页> 外文期刊>BJU international >Smoking is associated with worse outcomes in patients with prostate cancer treated by radical radiotherapy.
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Smoking is associated with worse outcomes in patients with prostate cancer treated by radical radiotherapy.

机译：根治性放疗治疗的前列腺癌患者吸烟与预后差有关。

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OBJECTIVE: To investigate the effect of smoking on the outcome in a cohort of men treated for localized prostate cancer at one institution with a uniform protocol of radical external beam radiotherapy (EBRT). PATIENTS AND METHODS: The study was a retrospective review of 434 patients with cT1-T4 N0m0 prostate cancer treated with curative intent with EBRT (66 Gy in 33 fractions) between 1990 and 1999. Univariate and multivariate Cox regression analyses were used to estimate the risk associated with smoking on biochemical failure (American Society for Therapeutic Radiology and Oncology definition), local failure, distant failure, overall and disease-specific survival. RESULTS: The median follow-up was 70.3 months. A smoking history was obtained in 96% of cases; 16.8% were current smokers, 54.4% previous smokers and 28.8% non-smokers. Current smokers presented at a younger median age, by 3.6 years (P = 0.06). There were no differences in clinical T stage, Gleason score or prostate-specific antigen level amongst the three patient groups. Smoking conferred a higher risk of developing metastatic disease in both current smokers (hazard ratio 5.24; 95% confidence interval 1.75-15.72) and previous smokers (2.90, 1.09-7.67). There were also increases in risk, although not quite significant, for biochemical failure (1.49, 0.88-2.40) and overall survival (1.72, 0.94-3.15). CONCLUSIONS: After curative treatment with EBRT, a history of smoking was associated with a greater risk of developing metastatic disease. Smoking status was not associated with worse disease on presentation.
机译：目的：研究吸烟对一所接受局限性放射外照射（EBRT）统一治疗的局限性前列腺癌男性患者预后的影响。患者与方法：本研究是对1990年至1999年间用EBRT进行治愈性意图治疗的434例cT1-T4 N0m0前列腺癌患者（66分Gy分为33份）的回顾性回顾。单因素和多因素Cox回归分析用于评估风险与吸烟有关的生化衰竭（美国放射治疗和肿瘤学会定义），局部衰竭，远距离衰竭，总体生存率和特定疾病生存率相关。结果：中位随访时间为70.3个月。 96％的患者有吸烟史;当前吸烟者为16.8％，以前吸烟者为54.4％，非吸烟者为28.8％。当前吸烟者的中位年龄较年轻，为3.6岁（P = 0.06）。在三个患者组之间，临床T期，格里森评分或前列腺特异性抗原水平无差异。在当前吸烟者（危险比5.24; 95％置信区间1.75-15.72）和以前吸烟者（2.90、1.09-7.67）中，吸烟均具有更高的患转移性疾病的风险。生化衰竭（1.49，0.88-2.40）和总生存（1.72，0.94-3.15）的风险也增加，尽管不是很明显。结论：用EBRT进行治愈性治疗后，吸烟史与患转移性疾病的风险更大有关。吸烟状态与病情加重无关。

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