When TRBP leaves Dicer at the alt-'ER

Hornstein Eran

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When TRBP leaves Dicer at the alt-'ER

机译：当TRBP让DICER处于所有内容时

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The principle underlying miRNA silencing seems rather simple: Dicer is required for the biogenesis of endogenous miRNAs, andmature miRNAs at the RNA-induced silencing complex, RISC, bind to targets bysequence complementary, inhibiting protein expression. However, research shows that there are many degrees of complexity to miRNA regulation. A new study by Antoniou etal that is published in this issue of EMBO Reports explores an interesting neuron-specific facet of miRNA biogenesis. We learn that in neuronal dendrites, the endoplasmic reticulum (ER) acts as a regulatory domain for the dynamic encounter of TRBP and Dicer, two proteins required for the biogenesis of miRNAs, thus affecting neuron morphogenesis.

机译：MiRNA沉默的原则似乎相当简单：内源性miRNA的生物发生需要Dicer，在RNA诱导的沉默复合物，RISC，抑制蛋白表达的靶向蛋白表达的靶向靶标复合物中的Anducous MiRNA。然而，研究表明对miRNA调节有很多程度的复杂性。在这个问题的Antoniou Etial上发表的一项新研究探讨了MiRNA生物生物发生的有趣的神经元特异性方面。我们在神经元树突中，内质网（ER）用作TRBP和DICER动态遇到的调节结构域，MIRNA生物发生所需的两种蛋白质，从而影响神经元形态发生。

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《EMBO reports》 |2018年第3期|共2页
作者
Hornstein Eran;
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Weizmann Inst Sci Dept Mol Genet Rehovot Israel;

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正文语种 eng
中图分类分子生物学;
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专利

1. When TRBP leaves Dicer at the alt-'ER [J] . Hornstein Eran EMBO reports . 2018,第3期

机译：当TRBP让DICER处于所有内容时
2. TRBP Dicer interaction may enhance HIV-1 TAR RNA translation via TAR RNA processing, repressing host-cell apoptosis [J] . Progress in Artificial Intelligence . 2020,第2期

机译：TRBP DICER相互作用可以通过焦油RNA加工增强HIV-1焦油RNA平移，压制宿主细胞凋亡
3. TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments [J] . Mohamed Fareh, Kyu-Hyeon Yeom, Anna C. Haagsma, Nature Communications . 2016,第1期

机译：TRBP确保在RNA拥挤的环境中对Dicer前体microRNA进行有效的Dicer处理
4. Characterization of diced ridge waveguides in pure and Er-doped lithium-niobate-on-insulator (LNOI) substrates [C] . C. E. Rueter, S. Suntsov, D. Kip, Optical components and materials XI . 2014

机译：在纯净和掺Er的绝缘子上铌酸锂（LNOI）衬底中切丁脊形波导的特性
5. Mechanisms of estrogen receptor (ER) action in breast cancer cells: Role of ER AF-1 domain in ER/SP-1 transactivation and modulation of ER by the ring finger coactivator SNURF. [D] . Saville, Bradley Martin. 2002

机译：乳腺癌细胞中雌激素受体（ER）作用的机制：ER AF-1域在无名指辅助激活剂SNURF的ER / SP-1反式激活和ER调节中的作用。
6. When TRBP leaves Dicer at the alt‐’ER [O] . Eran Hornstein 2018

机译：当TRBP离开Dicer进入Alt-’ER
7. Letter to the Editor "Drosha, DGCR8, and Dicer mRNAs are downregulated in human cells infected with dengue virus 4" - Genet. Mol. Res. 15 (2): gmr.15027891 - Drosha, Dicer, and TRBP mRNA are downregulated in Vero cells with the 3'UTR of Dengue virus [O] . J.A. Castillo, S. Urcuqui-Inchima 2016

机译：致编辑“Drosha，DGCR8和Dicer MRNA在用登革热病毒4” - Genet感染的人体细胞中下调。摩尔。 res。 15（2）：GMR.15027891 - DROSHA，DICER和TRBP mRNA在VERO细胞中下调与登革热病毒的3'URR
8. Seismic Measurements for the Pre-Dice Throw II-1 (TNT Shot),Pre-Dice Throw II-2 (AN/FO Shot) and Dice Throw Events. [R] . turpening, r. m. liskow, a. r. 1978

机译：预骰子投掷II-1（TNT射击），骰子投掷II-2（aN / FO射击）和骰子投掷事件的地震测量。

When TRBP leaves Dicer at the alt-'ER

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