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首页> 外文期刊>EMBO reports >Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia
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Fast neurogenesis from carotid body quiescent neuroblasts accelerates adaptation to hypoxia

机译：来自颈动脉体静态神经细胞的快速神经发生加速适应缺氧

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摘要

Unlike other neural peripheral organs, the adult carotid body (CB) has a remarkable structural plasticity, as it grows during acclimatization to hypoxia. The CB contains neural stem cells that can differentiate into oxygen-sensitive glomus cells. However, an extended view is that, unlike other catecholaminergic cells of the same lineage (sympathetic neurons or chromaffin cells), glomus cells can divide and thus contribute to CB hypertrophy. Here, we show that O-2-sensitive mature glomus cells are post-mitotic. However, we describe an unexpected population of pre-differentiated, immature neuroblasts that express catecholaminergic markers and contain voltage-dependent ion channels, but are unresponsive to hypoxia. Neuroblasts are quiescent in normoxic conditions, but rapidly proliferate and differentiate into matureglomus cells during hypoxia. This unprecedented "fast neurogenesis" is stimulated by ATP and acetylcholine released from mature glomus cells. CB neuroblasts, which may have evolved to facilitate acclimatization to hypoxia, could contribute to the CB oversensitivity observed in highly prevalent human diseases.
机译：与其他神经外周器官不同，成年颈动脉体（CB）具有显着的结构可塑性，因为它在依赖于缺氧期间生长。 CB含有神经干细胞，可以分化为氧敏感性肾小球细胞。然而，延长视图是，与相同谱系（交感神经元或斑粘蛋白细胞）的其他儿茶酚胺能细胞不同，Glomus细胞可以分开并因此有助于CB肥大。在这里，我们表明O-2敏感的​​成熟肾小球细胞是有丝分裂性的。然而，我们描述了表达儿茶酚胺能标记物并含有电压依赖性离子通道的预分化，未成熟的神经细胞的意外群体，但对缺氧无响应。神经细胞在常氧条件下是静态的，但在缺氧期间迅速增殖和分化成熟藻细胞。通过从成熟的Glomus细胞释放的ATP和乙酰胆碱刺激前所未有的“快神经发生”。可能已经进化以促进缺氧的CB神经细胞可能有助于在高度普遍的人类疾病中观察到的CB过敏。

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