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首页> 外文期刊>Endocrine. >Pituitary growth hormone (GH) secretion is partially rescued in HIV-infected patients with GH deficiency (GHD) compared to hypopituitary patients
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Pituitary growth hormone (GH) secretion is partially rescued in HIV-infected patients with GH deficiency (GHD) compared to hypopituitary patients

机译：与低钠携化患者相比，垂体生长激素（GH）分泌部分拯救在HIV感染患者（GHD）中拯救

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Biochemical growth hormone deficiency is prevalent among human immunodeficiency virus-infected patients, but if this condition is clinically relevant remains challenging. The aim is to prospectively compare the growth hormone deficiency/insulin-like growth factor-1 status of 71 human immunodeficiency virus-infected patients with impaired growth hormone response to growth hormone releasing hormone + Arginine with that of 65 hypopituitary patients affected by a true growth hormone deficiency secondary to pituitary disease. The main outcomes were: basal serum growth hormone, insulin-like growth factor-1, insulin-like growth factor binding protein 3, growth hormone peak and area under the curve after growth hormone response to growth hormone releasing hormone + Arginine test, body mass index, waist and hip circumference, and body composition by dual energy X-ray absorptiometry. Insulin-like growth factor-1 binding protein 3, basal growth hormone (p < 0.005), growth hormone peak and area under the curve after growth hormone response to growth hormone releasing hormone + Arginine, waist to hip ratio, insulin-like growth factor-1, fasting glucose, insulin, and triglycerides (p < 0.0001) were lower in hypopituitary than human immunodeficiency virus-infected patients. Total and trunk fat mass by dual energy X-ray absorptiometry were higher in hypopituitary than in human immunodeficiency virus-infected patients (p < 0.0001). In all the patients total body fat was associated with both growth hormone peak and area under the curve at stepwise linear regression analysis. The degree of growth hormone deficiency is more severe in hypopituitary than in human immunodeficiency virus-infected patients, suggesting that the function of growth hormone/insulin-like growth factor-1 axis is partially rescued in the latter thanks to a preserved pituitary secretory reserve. Data from the current study suggest that human immunodeficiency virus-infected patients with peak growth hormone < 9 mg/L may have partial growth hormone deficiency and clinicians should be cautious before prescribing recombinant human growth hormone replacement treatment to patients living with human immunodeficiency virus.
机译：生物化学生长激素缺乏症在人类免疫缺陷病毒感染患者中普遍存在，但如果这种情况在临床上相关仍然挑战。目的是将71人免疫缺陷病毒感染患者的生长激素缺乏/胰岛素样生长因子-1状态进行了预期比较增长激素对生长激素释放激素+精氨酸的生长激素+精氨酸的患者的增长激素响应障碍患者的增长障碍患者激素缺乏继发于垂体疾病。主要结果是：基础血清生长激素，胰岛素样生长因子-1，胰岛素样生长因子结合蛋白3，生长激素峰值和面积在曲线下的生长激素响应生长激素释放激素+精氨酸试验，体重通过双能X射线吸收测定法，腰部和臀部周长和身体组成。胰岛素样生长因子-1结合蛋白3，基底生长激素（p <0.005），生长激素峰和曲线下的面积在生长激素释放激素+精氨酸的生长激素+精氨酸，腰部比率，胰岛素样生长因子-1，空腹葡萄糖，胰岛素和甘油三酯（P <0.0001）低于人类免疫缺陷病毒感染患者的低钠。通过双能量X射线吸收测定法的总和和躯干脂肪质量低于人类免疫缺陷病毒感染患者（P <0.0001）。在所有患者中，总体脂肪在逐步线性回归分析下与曲线下的生长激素峰和面积相关联。增长激素缺乏程度比在人类免疫缺陷病毒感染患者中更严重，表明增长激素/胰岛素样生长因子-1轴的功能在后者的情况下，由于保存的垂体分泌储备，在后者部分地救出。目前研究的数据表明，人类免疫缺陷病毒感染患者的峰值生长激素<9毫克/升可能有部分生长激素缺乏症，临床医生应在规定重组人体生长激素替代治疗治疗人类免疫缺陷病毒的患者之前谨慎。

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