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首页> 外文期刊>BJU international >Antitumour effect of electrochemotherapy with bleomycin on human prostate cancer xenograft.
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Antitumour effect of electrochemotherapy with bleomycin on human prostate cancer xenograft.

机译：博来霉素电化学疗法对人前列腺癌异种移植物的抗肿瘤作用。

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OBJECTIVE: To investigate the antitumour effect of electroporation (EP), a drug delivery system that has been shown to be effective synergistically with antitumour drugs, with bleomycin on the growth of prostate cancer xenografts in nude mice. MATERIALS AND METHODS: PC-3 cells were implanted subcutaneously into nude mice. After determination of the optimal conditions of electric pulse voltage and bleomycin dose, tumour growth in mice treated with EP plus bleomycin was compared with that in mice receiving EP alone, bleomycin alone or no treatment. In all four groups, apoptosis in the tumours was assessed. RESULTS: There was a significant reduction in tumour growth in mice that received EP with bleomycin. Apoptotic cells in tumours at 24 h after treatment with EP plus bleomycin showed a significant difference compared with the other three groups, but not at 12 h after treatment. CONCLUSIONS: These results indicate the possibility that EP with bleomycin could be effective as an ablation therapy for prostate cancer, especially androgen-independent cancer.
机译：目的：研究电穿孔（EP）的抗肿瘤作用，该系统已证明与博莱霉素对抗肿瘤药物具有协同增效作用，博莱霉素对裸鼠体内前列腺癌异种移植物的生长具有促进作用。材料与方法：将PC-3细胞皮下植入裸鼠。在确定电脉冲电压和博来霉素剂量的最佳条件后，将用EP加博来霉素治疗的小鼠的肿瘤生长与仅接受EP，单独使用博来霉素或不接受EP的小鼠进行比较。在所有四个组中，评估了肿瘤中的细胞凋亡。结果：接受博来霉素EP的小鼠的肿瘤生长显着减少。 EP +博来霉素治疗后24 h肿瘤细胞凋亡与其他三组相比有显着差异，但治疗后12 h无明显变化。结论：这些结果表明，含博来霉素的EP可能作为前列腺癌特别是雄激素非依赖性癌症的消融治疗有效。

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