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首页> 外文期刊>Electroanalysis >Fabrication of the Enzyme-less Voltammetric Bilirubin Sensor Based on Sol-gel Imprinted Polymer
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Fabrication of the Enzyme-less Voltammetric Bilirubin Sensor Based on Sol-gel Imprinted Polymer

机译：基于溶胶 - 凝胶印迹聚合物的酶伏安胆红素传感器的制备

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摘要

Measuring the serum bilirubin (BR) level is part of the common test for newborns, since high concentrations of bilirubin in the blood can cause brain damage and even death for them. Therefore, achieving a fast, accurate and cost effective method for bilirubin assay in medical diagnosis and Medical management of patients with jaundice, especially neonates, is very important. In this study, an electrochemical sensor was developed to detect low amounts of bilirubin in serum samples. The basis of the work is the BR imprinted polymer synthesis and the use of this polymer as a recognition element in the production of the bilirubin voltammetric sensor. For this purpose, bilirubin imprinted polymer was synthesized using the simple sol gel method and the prepared polymer is characterized by SEM and FT-IR. In the next step, this polymer was applied to modify the carbon paste electrode and provide a sensitive and selective sensor for the BR molecule. The proposed sensor was able to measure the bilirubin in the concentration range of 1 to 100 mu M after optimizing the operating conditions. The limit of detection (LOD) and limit of quantification (LOQ) was calculated 0.75 mu M and 2.5 mu M respectively. It is also applicable to bilirubin assay in serum samples.
机译：测量血清胆红素（BR）水平是新生儿常见考验的一部分，因为血液中的高浓度胆红素会导致脑损伤甚至死亡。因此，在黄疸患者的医学诊断和医学管理中实现了快速，准确和成本效益的胆红素测定方法，特别是新生儿，非常重要。在该研究中，开发了一种电化学传感器以检测血清样品中的少量胆红素。该工作的基础是Br压印的聚合物合成和使用该聚合物作为胆红素伏安传感器的生产中的识别元件。为此目的，使用简单的溶胶凝胶法合成胆红素印迹聚合物，制备的聚合物的特征在于SEM和FT-IR。在下一步骤中，将该聚合物施加以改变碳浆料电极并为BR分子提供敏感和选择性传感器。在优化操作条件后，所提出的传感器能​​够测量1至100μm的浓度范围的胆红素。检测极限（LOD）和定量极限（LOQ）分别计算0.75μm和2.5μm。它还适用于血清样品中的胆红素测定。

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