Electrochemical Detection of Sialic Acid Using Phenylboronic Acid‐modified Poly(Diaminobenzoic Acid) Electrodes

Broncová Gabriela; Matějka Pavel; Něme?ková Zuzana; Vrkoslav Vladimír; Shishkanova Tatiana V.

摘要

Abstract > This study is focused on the electrochemical detection of sialic acid (SA) using electrochemical impedance spectroscopy (EIS) and potentiometric approaches with the polymeric film derived from 3,4‐diaminobenzoic acid (3,4‐DABA) and modified with 3‐aminophenylboronic acid (3‐APBA). The polymeric film derived from 3,4‐DABA was prepared using cyclic voltammetry at 0.5?M H <sub>2</sub> SO <sub>4</sub> on a platinum disc electrode from 0 to 1.20?V vs. Ag/AgCl and characterized by FTIR‐Raman spectroscopy. It has been found that the polymerization process goes through the amino group and a free carboxyl group serves for the covalent binding of 3‐APBA onto the polymeric backbone. Both the electrochemical approaches independently confirmed the recognition of SA by APBA‐modified PDABA electrodes. In contrast to known electrochemical sensors in the literature, the APBA‐modified PADABA sensor for SA gave a response in the range from 0.025 to 0.998?mM at neutral pH using the EIS method. The decrease in the EIS signal of ca 12?% was observed after two weeks of intensive use. Importantly, the selective APBA‐modified polymeric electrode enabled the use of SA determination in artificial urine samples in a concentration range that is useful for diagnostic purposes, specifically 12–102?μg?mL ?1 . </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >本研究专注于使用电化学阻抗光谱（ EIS）和电位方法与来自3,4-二氨基苯甲酸（3,4-达巴巴）的聚合物薄膜并用3-氨基苯基硼酸（3-APBA）改性。使用0.5ΩmH<sub> 2 SO <sub> 4 </ sub>在铂盘电极的0至1.20°-V与Ag上的旋转伏安衍生自3,4-daba的聚合物膜。Vs. Ag / AgCl并以FTIR-Raman光谱为特征。已经发现聚合过程通过氨基，并且游离羧基用于3-APBA的共价结合到聚合物主链上。通过APBA改性的PDABA电极独立地确认了电化学方法的识别。与文献中的已知电化学传感器相反，用于SA的APBA改性的PADABA传感器在使用EIS方法的中性pH值下的响应范围为0.025至0.998Ωmm。在密集使用两周后观察到Ca 12Δ％的EIS 12的降低。重要的是，选择性APBA改性的聚合物电极使得在用于诊断目的的浓度范围内使用SA测定，特别是用于诊断目的的浓度范围，特别是12-102Ω·μg≤1毫升 1。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-22546/'>《Electroanalysis》</a> <b style="margin: 0 2px;">|</b><span>2018年第4期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Broncová Gabriela&option=202" target="_blank" rel="nofollow">Broncová Gabriela;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Matějka Pavel&option=202" target="_blank" rel="nofollow">Matějka Pavel;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Něme?ková Zuzana&option=202" target="_blank" rel="nofollow">Něme?ková Zuzana;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Vrkoslav Vladimír&option=202" target="_blank" rel="nofollow">Vrkoslav Vladimír;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Shishkanova Tatiana V.&option=202" target="_blank" rel="nofollow">Shishkanova Tatiana V.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Analytical ChemistryUniversity of Chemistry and Technology PragueTechnická 5 CZ-166 28 Prague 6 Czech Republic;</p> <p>Department of Physical ChemistryUniversity of Chemistry and Technology PragueTechnická 5 CZ-166 28 Prague 6 Czech Republic;</p> <p>Department of Analytical ChemistryUniversity of Chemistry and Technology PragueTechnická 5 CZ-166 28 Prague 6 Czech Republic;</p> <p>Institute of Organic Chemistry and Biochemistry of the Czech Academy of SciencesFlemingovo nám. 2 CZ-166 10 Prague 6 Czech Republic;</p> <p>Department of Analytical ChemistryUniversity of Chemistry and Technology PragueTechnická 5 CZ-166 28 Prague 6 Czech Republic;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/4817.html" title="电化学、电解、磁化学">电化学、电解、磁化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Diaminobenzoic Acid&option=203" rel="nofollow">Diaminobenzoic Acid;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Electrodeposition&option=203" rel="nofollow">Electrodeposition;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Phenylboronic Acid Modification&option=203" rel="nofollow">Phenylboronic Acid Modification;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sialic Acid&option=203" rel="nofollow">Sialic Acid;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sensors&option=203" rel="nofollow">Sensors;</a> </p> <div class="translation"> 机译：二氨基苯甲酸;电沉积;苯硼酸改性;唾液酸;传感器; 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