Pattern Recognition of Diabetes Related Biomarkers

Stefan‐van?Staden Raluca‐Ioana; Mitrofan Grigorina; Ionescu‐Tirgoviste Constantin

摘要

Abstract > Four stochastic microsensors were proposed for the molecular recognition of insulin, Proinsulin C Peptide (55–89), leptin, adiponectin and CRP in serum samples. The microsensors were design by physical immobilization of protoporphyrin PIX, phthalocyanine‐BODIPY dye (BODIPY=boron dipyrromethene), inulins such as TEX or ionic liquids such as L‐alanine‐tert‐butyl‐ester‐L‐lactate (L‐AlaC <sub>4</sub> ‐Lac) in matrices such as diamond paste and Au‐TiO <sub>2</sub> /rGR paste. The proposed microsensors were reliable for the molecular recognition and quantification of the biomarkers. For the determination of Proinsulin C Peptide (55–89), insulin, leptin, adiponectin and CRP the immunoassay techniques are routinely used in clinical practice, requiring five types of detection kits, therefore one of the main advantage in using this method consists in determining in one run all the analytes. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract type =“main”xml：lang =“en”> <标题类型=“main”>抽象</ title> >四个随机微传感器被提出用于胰岛素的分子识别，胰岛素c肽（55-89 ），瘦素，脂联素和血清样品中的CRP。通过原子卟啉Pix的物理固定，酞菁 - Bodipy染料（BODIPY =硼双甲烯），诸如Tex或离子液体如L-丙氨酸 - 叔丁基 - 酯-1-乳酸（L-ALAC <SUB等> 4 </ sub> -LAC）在矩阵，如金刚石糊和Au-TiO <sub> 2 </ sub> / RGR粘贴。所提出的微传感器对于生物标志物的分子识别和定量是可靠的。为了测定胰岛素C肽（55-89），胰岛素，瘦素，脂联素和CRP，免疫测定技术是常规的临床实践，需要五种类型的检测试剂盒，因此使用该方法的主要优点之一包括确定一次运行所有分析物。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-22546/'>《Electroanalysis》</a> <b style="margin: 0 2px;">|</b><span>2018年第11期</span><b style="margin: 0 2px;">|</b><span>共7页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Stefan‐van?Staden Raluca‐Ioana&option=202" target="_blank" rel="nofollow">Stefan‐van?Staden Raluca‐Ioana;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mitrofan Grigorina&option=202" target="_blank" rel="nofollow">Mitrofan Grigorina;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ionescu‐Tirgoviste Constantin&option=202" target="_blank" rel="nofollow">Ionescu‐Tirgoviste Constantin;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Laboratory of Electrochemistry and PATLAB BucharestNational Institute of Research for Electrochemistry and Condensed Matter 202Splaiul Independentei St. Bucharest 060021 Romania;</p> <p>Faculty of Applied Chemistry and Materials SciencePolitehnica University of Bucharest 1-7 Polizu St. Bucharest 011061 Romania;</p> <p>National Institute of DiabetesNutrition and Metabolic Diseases“N.C. Paulescu” Bucharest Romania;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/4817.html" title="电化学、电解、磁化学">电化学、电解、磁化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Diabetes&option=203" rel="nofollow">Diabetes;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=insulin&option=203" rel="nofollow">insulin;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Proinsulin C Peptide (55–89)&option=203" rel="nofollow">Proinsulin C Peptide (55–89);</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=leptin&option=203" rel="nofollow">leptin;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=adiponectin&option=203" rel="nofollow">adiponectin;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=CRP&option=203" rel="nofollow">CRP;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=stochastic sensors&option=203" rel="nofollow">stochastic sensors;</a> </p> <div class="translation"> 机译：糖尿病;胰岛素;胰岛素C肽（55-89）;瘦素;脂联素;CRP;随机传感器; 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href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=邓玉林&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 邓玉林</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=李浡&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,李浡</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=彭博&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,彭博</a> <span> <a href="/conference-cn-17039/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第十七届全国色谱学术报告会 </a> <span> <span> . 2009</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/02031991338.html">农村地区成人2型糖尿病发生风险相关生物标志物的筛选及预测模型的建立</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=文江平&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 文江平</a> <span> . 2016</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120113383071.html">与糖尿病肾病发生发展相关的生物标志物及其应用</a> <b>[P]</b> . <span> 中国专利： CN113416777A </span> <span> . 2021-09-21</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120107288337.html">作为糖尿病的生物标志物的CMPF和相关方法</a> <b>[P]</b> . <span> 中国专利： CN104822378A </span> <span> . 2015-08-05</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130418465094.html">System, method and computer program code for recognition of hyperglycemia and hypoglycemia patterns, increased glucose variability, and invalid self-monitoring in diabetes</a> <b>[P]</b> . <span> 外国专利：  JP5435862B2 </span> <span> . 2014-03-05</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：用于识别高血糖和低血糖模式，增加的葡萄糖变异性以及糖尿病患者无效自我监测的系统，方法和计算机程序代码 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130429720797.html">Systems, methods and computer program codes for recognition of patterns of hyperglycemia and hypoglycemia, increased glucose variability, and ineffective self-monitoring in diabetes</a> <b>[P]</b> . <span> 外国专利：  EP1956371A3 </span> <span> . 2009-03-18</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：系统，方法和计算机程序代码，用于识别糖尿病的高血糖和低血糖模式，增加的葡萄糖变异性以及无效的自我监测 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130433150646.html">Systems, Methods and Computer Program Codes for Recognition of Patterns of Hyperglycemia and Hypoglycemia, Increased Glucose Variability, and Ineffective Self-Monitoring in Diabetes</a> <b>[P]</b> . <span> 外国专利：  US2008154513A1 </span> <span> . 2008-06-26</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：系统，方法和计算机程序代码，用于识别糖尿病的高血糖和低血糖模式，增加的葡萄糖变异性以及无效的自我监测 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704023174153','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="关闭" 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