A Simple and Highly Selective Determination of Telmisartan at Sodium Dodecyl Sulfate Modified Pyrolytic Graphite Surface

Kumar Neeraj; Goyal Rajendra N.

摘要

Abstract >A simple, facile, selective and cost effective electrochemical method is proposed for the determination of telmisartan (TMS); a drug used for hypertension. A sodium dodecyl sulfate (SDS) modified edge plane pyrolytic graphite (EPPG) is prepared by simple immersion of EPPG in SDS solution at concentration greater than critical micelle concentration (CMC). The modified sensor exhibited superior sensing properties towards the oxidation of TMS. The modified surface was characterized by using the Energy dispersive X‐ray analysis, Field Emission Scanning Electron Microscopy, Electrochemical Impedance Spectroscopy and cyclic voltammetry. The quantitative investigations of the TMS were performed by applying the square wave voltammetry. The micelles of SDS form a pseudo complex with cation radical of TMS and catalyse the oxidation. The proposed sensor shows the linear calibration plot in the concentration range of 5–100?μM with sensitivity 0.2983?μA/μM and the limit of the detection of the sensor was found to be 0.082?μM. The specificity of the developed sensor was also evaluated in the presence of commonly present interfering substances in biological samples. The amount of TMS excreted in urine of the patients undergoing treatment has also been determined. The proposed method can be effectively applied for the investigation of TMS in pharmaceutical formulations and biological samples. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >简单，容易，选择性和成本有效的电化学方法，用于确定Telmisartan（ TMS）;用于高血压的药物。通过在浓度大于临界胶束浓度（CMC）的SDS溶液中简单地浸入EPPG，制备十二烷基硫酸钠（SDS）改性边缘平面热解石墨（EPPG）。改性传感器朝向TMS氧化表现出优异的感测性能。通过使用能量分散X射线分析，场发射扫描电子显微镜，电化学阻抗光谱和循环伏安法来表征改性表面。通过施加方波伏安法进行TMS的定量研究。 SDS的胶束形成具有TMS的阳离子的伪络合物并催化氧化。所提出的传感器显示浓度范围内的线性校准图，浓度范围为5-100Ωμm，灵敏度为0.2983≤μA/μm，发现传感器的检测限为0.082ΩΩμm。还在生物样品中通常存在干扰物质存在的情况下评估发育传感器的特异性。还确定了在进行治疗的患者的尿液中排出的TMS的量。该方法可以有效地应用于药物制剂和生物样品中TMS的研究。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-22546/'>《Electroanalysis》</a> <b style="margin: 0 2px;">|</b><span>2018年第5期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kumar Neeraj&option=202" target="_blank" rel="nofollow">Kumar Neeraj;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Goyal Rajendra N.&option=202" target="_blank" rel="nofollow">Goyal Rajendra N.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of ChemistryIndian Institute of Technology RoorkeeRoorkee – 247 667 India;</p> <p>Department of ChemistryIndian Institute of Technology RoorkeeRoorkee – 247 667 India;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/4817.html" title="电化学、电解、磁化学">电化学、电解、磁化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Telmisartan&option=203" rel="nofollow">Telmisartan;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sodium dodecyl sulfate&option=203" rel="nofollow">Sodium dodecyl sulfate;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=sensor&option=203" rel="nofollow">sensor;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=voltammetry&option=203" rel="nofollow">voltammetry;</a> </p> <div class="translation"> 机译：Telmisartan;十二烷基硫酸钠;传感器;伏安法; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023174293.html">A Simple and Highly Selective Determination of Telmisartan at Sodium Dodecyl Sulfate Modified Pyrolytic Graphite Surface</a> 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</div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130436640911.html">Preparing interleukin-2 (IL-2) for pharmaceutical use, by adding sodium dodecyl sulfate to composition comprising IL-2, removing precipitated covalently-linked IL-2 multimers, and reducing sodium dodecyl sulfate concentration</a> <b>[P]</b> . <span> 外国专利：  DE102005005542A1 </span> <span> . 2006-08-10</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过将十二烷基硫酸钠添加到包含IL-2的组合物中，去除沉淀的共价连接的IL-2多聚体并降低十二烷基硫酸钠的浓度来制备可用于药物用途的白介素2（IL-2） </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130436449121.html">Preparing interleukin-2 (IL-2) for pharmaceutical use, by adding sodium dodecyl sulfate to composition comprising IL-2, removing precipitated covalently-linked IL-2 multimers, and reducing sodium dodecyl sulfate concentration</a> <b>[P]</b> . <span> 外国专利：  FR2881655A3 </span> <span> . 2006-08-11</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过将十二烷基硫酸钠添加到包含IL-2的组合物中，去除沉淀的共价连接的IL-2多聚体并降低十二烷基硫酸钠的浓度来制备可用于药物用途的白介素2（IL-2） </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130467300745.html">Method of removing sodium dodecyl sulfate from sodium dodecyl sulfate solubilised protein solutions</a> <b>[P]</b> . <span> 外国专利：  EP0291349A3 </span> <span> . 1989-09-27</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：从十二烷基硫酸钠溶解的蛋白质溶液中去除十二烷基硫酸钠的方法 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> 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