Oral Cancer Screening Based on Methylation Frequency Detection in <i xmlns='http://www.wiley.com/namespaces/wiley'>hTERThTERT Gene Using Electrochemical Hybridization Assay via a Multi‐electrode Chip Coupled with Ferrocenylnaphthalene Diimide

Haraguchi Kazuya; Sato Shinobu; Habu Manabu; Yada Naomi; Hayakawa Mana; Takahashi Osamu; Yoshioka Izumi; Matsuo Kou; Tominaga Kazuhiro; Takenaka Shigeori

摘要

Abstract > Ferrocenylnaphthalene diimide‐based electrochemical hybridization assay via a multi‐electrode chip was applied to detect the methylation frequency in the promoter region of human telomerase reverse transcriptase ( hTERT ) gene for clinical samples from tissues, local exfoliated oral cells from a lesion, or from entire oral cavity after their methylation specific PCRs. These methylation frequencies were increased with cancer progress as the following order: healthy volunteers, oral leukoplakia as precancerous lesion, and oral squamous cell carcinoma (OSCC). Operating characteristic analysis of the obtained current data doesn't only give excellent discrimination ability of OSCC, but also of oral leukoplakia from healthy volunteers for all samples. Sensitivity and specificity was 95?% and 90?%, respectively, which is a comparable with methods in practical use. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <title type =“main”>摘录</ title> >二茂环氧萘二酰亚胺基于多电极芯片的电化学杂交测定被施用以检测人端粒酶逆转录酶的启动子区域中的甲基化频率（ HTERT </ i>）基因，用于来自组织的临床样品，来自病变的局部去角质的口腔细胞，或在其甲基化特异性PCR后的整个口腔中。这些甲基化频率随着癌症进展而增加，作为以下命令：健康的志愿者，口服白斑作为癌前病变，口腔鳞状细胞癌（OSCC）。所获得的电流数据的操作特征分析不仅为OSCC提供了良好的辨别能力，还具有来自所有样品的健康志愿者的口腔白血病。敏感性和特异性分别为95？％和90？％，其是与实际用途中的方法相当。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-22546/'>《Electroanalysis》</a> <b style="margin: 0 2px;">|</b><span>2017年第6期</span><b style="margin: 0 2px;">|</b><span>共6页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Haraguchi Kazuya&option=202" target="_blank" rel="nofollow">Haraguchi Kazuya;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sato Shinobu&option=202" target="_blank" rel="nofollow">Sato Shinobu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Habu Manabu&option=202" target="_blank" rel="nofollow">Habu Manabu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yada Naomi&option=202" target="_blank" rel="nofollow">Yada Naomi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hayakawa Mana&option=202" target="_blank" rel="nofollow">Hayakawa Mana;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Takahashi Osamu&option=202" target="_blank" rel="nofollow">Takahashi Osamu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yoshioka Izumi&option=202" target="_blank" rel="nofollow">Yoshioka Izumi;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Matsuo Kou&option=202" target="_blank" rel="nofollow">Matsuo Kou;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tominaga Kazuhiro&option=202" target="_blank" rel="nofollow">Tominaga Kazuhiro;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Takenaka Shigeori&option=202" target="_blank" rel="nofollow">Takenaka Shigeori;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Science of Physical FunctionsKyushu Dental University2-6-1 Manazuru Kokurakitaku Kitakyushu Fukuoka 803-8580 Japan;</p> <p>Department of Applied Chemistry and Research Center for Bio-microsensing TechnologyKyushu Institute of Technology1-1 Sensui Tobataku Kitakyushu Fukuoka 804-8550 Japan;</p> <p>Department of Science of Physical FunctionsKyushu Dental University2-6-1 Manazuru Kokurakitaku Kitakyushu Fukuoka 803-8580 Japan;</p> <p>Department of Health Promotion Division of Oral PathologyKyushu Dental University2-6-1 Manazuru Kokurakitaku Kitakyushu Fukuoka 803-8580 Japan;</p> <p>Department of Science of Physical FunctionsKyushu Dental University2-6-1 Manazuru Kokurakitaku Kitakyushu Fukuoka 803-8580 Japan;</p> <p>Department of Science of Physical FunctionsKyushu Dental University2-6-1 Manazuru Kokurakitaku Kitakyushu Fukuoka 803-8580 Japan;</p> <p>Department of Science of Physical Functions Division of Oral MedicineKyushu Dental University2-6-1 Manazuru Kokurakitaku Kitakyushu Fukuoka 803-8580 Japan;</p> <p>Department of Health Promotion Division of Oral PathologyKyushu Dental University2-6-1 Manazuru Kokurakitaku Kitakyushu Fukuoka 803-8580 Japan;</p> <p>Department of Science of Physical FunctionsKyushu Dental University2-6-1 Manazuru Kokurakitaku Kitakyushu Fukuoka 803-8580 Japan;</p> <p>Department of Applied Chemistry and Research Center for Bio-microsensing TechnologyKyushu Institute of Technology1-1 Sensui Tobataku Kitakyushu Fukuoka 804-8550 Japan;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/4817.html" title="电化学、电解、磁化学">电化学、电解、磁化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Human telomerase reverse transcriptase ( hTERT ) gene&option=203" rel="nofollow">Human telomerase reverse transcriptase ( hTERT ) gene;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=aberrant methylation&option=203" rel="nofollow">aberrant methylation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=oral cancer screening&option=203" rel="nofollow">oral cancer screening;</a> </p> <div class="translation"> 机译：人端粒酶逆转录酶（HTERT）基因;异常甲基化;口腔癌筛查; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> </ul> </div> <div 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Oral Cancer Screening Based on Methylation Frequency Detection in hTERThTERT Gene Using Electrochemical Hybridization Assay via a Multi‐electrode Chip Coupled with Ferrocenylnaphthalene Diimide

摘要