Online Electrochemical Monitoring of Glucose in Rat Brain with Acanthosphere‐like CuOOH Nanospheres‐based Electrochemical Sensor as Non‐enzymatic and O        <sub >2</sub>2        ‐independent Detector

Li Bo; Fan Yongzhao; Li Changqing; Zhao Xu; Liu Kun; Lin Yuqing

摘要

Abstract > This study for the first time establishes a reliable non‐enzymatic online electrochemical system (OECS) for selective and continuous measuring glucose in animal cerebral system. We proposed a one‐step electrochemical method to synthetize a Cu nanostructure directly onto electrode, and over‐oxidize it in NaOH to form acanthosphere‐like CuOOH nanospheres (denoted as AN‐CuOOH), which can serve as an excellent electrochemical catalyst for glucose oxidation and thus for simple and reproducible non‐enzymatic glucose detection in strong alkaline solution. To validate the AN‐CuOOH‐based sensors for in vivo applications, we connect the sensors to a merged solution of in vivo microdialysis and 0.4?M NaOH to set up an OECS for in vivo glucose monitoring in rat brain. The response of this system has strong tolerance to the oxygen and pH fluctuation which may happen in the cerebral brain system during some physiological and pathological processes. The fabricated non‐enzymatic OECS has a good linear current response to glucose within a concentration range from 10 to 1000?μΜ with sensitivity of 130.22?nA???μΜ ?1 ?cm ?2 . Additionally, the OECS is stable and does not suffer from the interference coexisting in the cerebral system. With the fabricated non‐enzymatic OECS for glucose measurement, the basal level of glucose in the microdialysate from rats striatum was determined to be 248.63?μΜ (n=3). Furthermore, the glucose was clearly decreased to 26.37?% of the basal level when the rat was undergone by 20?min ischemia, and the glucose concentration was gradually restored to 99.15?% during 40?min of reperfusion. Our work propose a technically simple strategy for the fabrication of a highly reproducible non‐enzymatic OECS system free from </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >本研究首次建立了可靠的非酶网电化学系统（OECs）动物脑系统中的选择性和连续测量葡萄糖。我们提出了一种单步电化学方法，将Cu纳米结构直接合成电极上，并在NaOH中过度氧化它以形成刺激性的CuOH纳米球（表示为-CuOH），其可以用作葡萄糖氧化的优异电化学催化剂因此，对于强碱溶液中的简单且可重复的非酶促葡萄糖检测。为了在Vivo <I>中验证基于AN-CUOOH的传感器，我们将传感器连接到vivo </ i>微透析的合并解决方案，0.4？M NaOH设置OEC对于在大鼠脑中的葡萄糖监测中，对于血糖监测的。该系统的响应对氧气和pH波动具有很强的耐受性，在某些生理和病理过程中可能在脑脑系统中发生。制造的非酶的OECs具有良好的线性电流对浓度范围内的葡萄糖的良好线性电流响应，其浓度为10至1000ΩΩμm，其灵敏度为130.22Ω·na≤naΩμmΔ1///βcm？2 </ sup>。另外，OECs是稳定的并且不会患上脑系统中的干扰共存。对于用于葡萄糖测量的制造的非酶促剂量，测定来自大鼠纹状体的微透明酸盐中的葡萄糖的基础水平为248.63Ω（n = 3）。此外，当大鼠经历20μmIm缺血时，葡萄糖明显降低至基底水平的26.37％，并且葡萄糖浓度逐渐恢复至再灌注40℃的99.15℃。我们的工作提出了一种技术上简单的策略，用于制造一个高度可重复的非酶的OECS系统系统 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-22546/'>《Electroanalysis》</a> <b style="margin: 0 2px;">|</b><span>2018年第6期</span><b style="margin: 0 2px;">|</b><span>共8页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Bo&option=202" target="_blank" rel="nofollow">Li Bo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Fan Yongzhao&option=202" target="_blank" rel="nofollow">Fan Yongzhao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Changqing&option=202" target="_blank" rel="nofollow">Li Changqing;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhao Xu&option=202" target="_blank" rel="nofollow">Zhao Xu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Kun&option=202" target="_blank" rel="nofollow">Liu Kun;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lin Yuqing&option=202" target="_blank" rel="nofollow">Lin Yuqing;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of ChemistryCapital Normal UniversityBeijing 100048 China;</p> <p>Capital University of Physical Education and SportsBeijing 100191 P. R. China;</p> <p>Department of ChemistryCapital Normal UniversityBeijing 100048 China;</p> <p>Department of ChemistryCapital Normal UniversityBeijing 100048 China;</p> <p>Capital University of Physical Education and SportsBeijing 100191 P. R. China;</p> <p>Department of ChemistryCapital Normal UniversityBeijing 100048 China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/4817.html" title="电化学、电解、磁化学">电化学、电解、磁化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Non-enzymatic detection&option=203" rel="nofollow">Non-enzymatic detection;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Online electrochemical system&option=203" rel="nofollow">Online electrochemical system;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=In vivo&option=203" rel="nofollow">In vivo;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Glucose&option=203" rel="nofollow">Glucose;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Acanthosphere-like CuOOH nanospheres&option=203" rel="nofollow">Acanthosphere-like CuOOH nanospheres;</a> </p> <div class="translation"> 机译：非酶促检测;在线电化学系统;在体内;葡萄糖;奇天际层状CUOOH纳米球; 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Online Electrochemical Monitoring of Glucose in Rat Brain with Acanthosphere‐like CuOOH Nanospheres‐based Electrochemical Sensor as Non‐enzymatic and O 22 ‐independent Detector

摘要

Online Electrochemical Monitoring of Glucose in Rat Brain with Acanthosphere‐like CuOOH Nanospheres‐based Electrochemical Sensor as Non‐enzymatic and O ₂2 ‐independent Detector