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首页> 外文期刊>BJU international >Free prostate-specific antigen 'in the field': a useful adjunct to standard clinical practice.
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Free prostate-specific antigen 'in the field': a useful adjunct to standard clinical practice.

机译：游离的前列腺特异性抗原“在现场”：是标准临床实践的有用辅助手段。

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摘要

OBJECTIVES: To determine the clinical utility of the ratio of free to total prostate-specific antigen (f/tPSA), which may improve the discrimination of PSA testing in the assessment of patients with prostatic disease, in a busy clinical practice. PATIENTS AND METHODS: A series of 198 men undergoing transrectal ultrasonography (TRUS)-guided biopsy, because of a high total PSA level or an abnormal digital rectal examination or both, had blood samples taken for the assessment of both free and total PSA before any form of prostatic manipulation. The histological findings were compared with tPSA, fPSA and f/tPSA, evaluating three different thresholds of f/tPSA. RESULTS: PSA levels, PSA density and fPSA density differed significantly between those with benign histology and neoplasia. The f/tPSA only differed significantly in men with a PSA level of 10. 1-15 ng/mL. The f/tPSA threshold of 0.25 was the most useful clinically, with a negative predictive value for prostate cancer of 91%. Using this threshold would reduce the negative biopsy rate by 30%. CONCLUSION: The f/tPSA is of clinical value in reducing the negative biopsy rate and in the management of patients with a high PSA level and previous negative biopsies.
机译：目的：在繁忙的临床实践中，确定游离抗原与总前列腺特异性抗原（f / tPSA）之比的临床用途，以改善PSA检测在评估前列腺疾病患者中的辨别力。患者和方法：由于高总PSA水平或数字直肠检查异常或两者兼而有之，对198名接受经直肠超声（TRUS）引导的活检的男性进行了血样采集，以评估游离PSA和总PSA。前列腺操纵的形式。将组织学结果与tPSA，fPSA和f / tPSA进行比较，评估f / tPSA的三个不同阈值。结果：在良性组织学和瘤形成的患者中，PSA水平，PSA密度和fPSA密度显着不同。 f / tPSA仅在PSA水平为10。1-15ng / mL的男性中有显着差异。 f / tPSA阈值0.25是临床上最有用的，对前列腺癌的阴性预测值为91％。使用此阈值将使活检阴性率降低30％。结论：f / tPSA在降低阴性组织活检率和治疗高PSA水平且先前阴性组织活检的患者中具有临床价值。

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