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首页> 外文期刊>Epigenetics: official journal of the DNA Methylation Society >Long noncoding RNA expression in the cervix mid-pregnancy is associated with the length of gestation at delivery
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Long noncoding RNA expression in the cervix mid-pregnancy is associated with the length of gestation at delivery

机译：宫颈中期妊娠中的长度非编码RNA表达与交付时的妊娠长度有关

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Infants born preterm are at increased risk of multiple morbidities and mortality. Why some women deliver preterm remains poorly understood. Prior studies have shown that cervical microRNA expression and DNA methylation are associated with the length of gestation. However, no study has examined the role of long noncoding RNAs (lncRNAs) in the cervix during pregnancy. To determine whether expression of lncRNAs is associated with length of gestation at delivery, we analyzed RNA from cervical swabs obtained from 78 women during pregnancy (mean 15.5, SD 5.0, weeks of gestation) who were participating in the Spontaneous Prematurity and Epigenetics of the Cervix (SPEC) Study in Boston, MA, USA. We used a PCR-based platform and found that 9 lncRNAs were expressed in at least 50% of the participants. Of these, a doubling of the expression of TUG1, TINCR, and FALEC was associated with shorter lengths of gestation at delivery [2.8 (95% CI: 0.31, 5.2); 3.3 (0.22, 6.3); and 4.5 (7.3, 1.6) days shorter respectively]. Of the lncRNAs analyzed, none was statistically associated with preterm birth, but expression of FALEC was 2.6-fold higher in women who delivered preterm vs. term (P = 0.051). These findings demonstrate that lncRNAs can be measured in cervical samples obtained during pregnancy and are associated with subsequent length of gestation at delivery. Further, this study supports future work to replicate these findings in other cohorts and perform mechanistic studies to determine the role of lncRNAs in the cervix during pregnancy.
机译：婴儿出生的早产是增加了多种病理和死亡率的风险。为什么有些女性递送早产仍然很糟糕。先前的研究表明，宫颈microRNA表达和DNA甲基化与妊娠的长度有关。然而，在怀孕期间，没有研究在妊娠期间患有长度非编码的RNA（LNCRNA）在子宫颈中的作用。为了确定LNCRNA的表达是否与妊娠的妊娠长度相关，我们分析了在妊娠期间78名女性获得的宫颈拭子的RNA（平均15.5，妊娠，妊娠期）是参与子宫颈的自发活力和表观遗传学（规格）在美国马士顿的研究。我们使用了基于PCR的平台，发现9个LNCRNA在至少50％的参与者中表达。其中，Tug1，Tincr和Falec表达的加倍与递送的妊娠长度较短相关[2.8（95％Ci：0.31,5.2）; 3.3（0.22,6.3）; 4.5（7.3,1.6）天分别短。在分析的LNCRNA的情况下，没有与早产有统计学相关的，但在递送早产与术语的女性中，Falec的表达比患者更高（P = 0.051）。这些发现表明，可以在妊娠期间获得的宫颈样品中测量LNCRNA，并且与递送时随后的妊娠期相关。此外，本研究支持未来的工作，以在其他队列中复制这些发现，并进行机械研究，以确定妊娠期间宫颈中的LNCRNA在子宫颈中的作用。

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