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首页> 外文期刊>Environmental Science: Processes & Impacts >Temporal trends of suspect- and target-per/polyfluoroalkyl substances (PFAS), extractable organic fluorine (EOF) and total fluorine (TF) in pooled serum from first-time mothers in Uppsala, Sweden, 1996-2017
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Temporal trends of suspect- and target-per/polyfluoroalkyl substances (PFAS), extractable organic fluorine (EOF) and total fluorine (TF) in pooled serum from first-time mothers in Uppsala, Sweden, 1996-2017

机译：来自瑞典乌普萨拉州乌普萨拉的首次母亲的嫌疑人和靶/聚氟烷基物质（PFA），可提取的有机氟（EOF）和总氟（TF）的颞次趋势

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A combined method for quantitative analysis, along with suspect and non-target screening of per- and polyfluoroalkyl substances (PFAS) was developed using ultra-high pressure liquid chromatography-ultra-high resolution (Orbitrap) mass spectrometry. The method was applied together with measurements of total- and extractable organofluorine (TF and EOF, respectively), to pooled serum samples from 1996-2017 from first-time mothers living in the county of Uppsala, Sweden, some of which (i.e.148 of 472 women sampled 1996-2012) were exposed to drinking water contaminated with perfluorohexane sulfonate (PFHxS) and other PFAS until mid-2012. Declining trends were observed for all target PFAS as well as TF, with homologue-dependent differences in year of onset of decline. Only 33% of samples displayed detectable EOF, and amongst these samples the percentage of EOF explained by target PFAS declined significantly (-3.5% per year) over the entire study period. This finding corroborates prior observations in Germany after the year 2000, and may reflect increasing exposure to novel PFAS which have not yet been identified. Suspect screening revealed the presence of perfluoro-4-ethylcyclohexanesulfonate (PFECHS), which displayed declining trends since the year 2000. Non-target time trend screening revealed 3 unidentified features with time trends matching PFHxS. These features require further investigation, but may represent contaminants which co-occurred with PFHxS in the contaminated drinking water.
机译：使用超高压液相色谱 - 超高分辨率（Orbitrap）质谱法开发了多氟烷基物质（PFAS）的定量分析的组合方法，以及多氟烷基物质（PFAS）的患者和非靶筛选。该方法与总可有机氟量（分别的有机氟荧光（TF和EOF）的测量相同，从1996 - 2017年汇集血清样本，从瑞典乌普萨拉县的第一次母亲那里到其中一些（IE148 472妇女采样1996-2012）暴露于用全氟己烷磺酸盐（PFHX）和其他PFA污染的饮用水直至2012年中期。针对所有目标PFA和TF观察到趋势下降，同源依赖性差异在发病的情况下。只有33％的样品显示可检测到的EOF，并且在这些样本中，在整个研究期间，目标PFA解释的EOF的百分比显着下降（每年3.5％）。这一发现在2000年之后的德国的先前观察结果，并可能反映出尚未确定的新型PFA的越来越多。怀疑筛选揭示了自2000年自2000年以来的全氟-4-乙基环己酰氨酸磺酸盐（Pfechs）的存在。非目标时间趋势筛查显示3个未识别的特征，时间趋势与PFHX匹配。这些特征需要进一步调查，但可以代表污染的饮用水中与PFHX共同发生的污染物。

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