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首页> 外文期刊>Epilepsia: Journal of the International League against Epilepsy >Coexistence of symptomatic focal and absence seizures: Video-EEG and EEG-fMRI evidence of overlapping but independent epileptogenic networks
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Coexistence of symptomatic focal and absence seizures: Video-EEG and EEG-fMRI evidence of overlapping but independent epileptogenic networks

机译:症状焦点和缺失的共存:视频EEG和EEG-FMRI重叠但独立癫痫型网络的证据

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SUMMARY:The distinction between typical absences and hypo-motor seizures in patients having frontal lesions is difficult. In focal epilepsy, generalized-like interic-tal discharges can reflect either a coexistent generalized epileptic trait or a secondary bilateral synchrony. Using combined measures of the EEG and blood oxygenation level dependent (BOLD) activity, we studied a 50-year-old patient with both absence-like and symptomatic focal motor seizures. Focal activity induced activation in the le-sional area and deactivation in the contralateral central cortex. Generalized spike-and-wave discharges (GSWDs) resulted also in perilesional activation, and multifocal symmetrical cortical and thalamic activations, and deactivation in associative cortical areas. Although the central cortex was involved during both types of epileptic activity, electroencephalography (EEG)-functional magnetic resonance imaging (fMRI) revealed distinct neuronal networks at the time of the focal or generalized discharges, allowing a clear-cut differentiation of the generators. Whether the patient had distinct epileptic syndromes or distinct elect-rographic patterns from the lesional trigger remains debatable.
机译:摘要:难以缺席患者的典型缺席和缺氧癫痫发作的区别。在局灶性癫痫中,相互化的间间缩小放电可以反映共存的广义癫痫特性或二级双侧同步。利用脑血液氧化水平依赖(粗体)活性的组合措施,我们研究了一个50岁的患者,缺乏症状和症状焦平电机癫痫发作。局灶性活性在对侧中央皮层中le-sational区的激活和去激活。广义峰值和波放电(GSWD)也导致涉及涉及的多灶性对称皮质和丘脑激活,并在联想皮质区域中停用。虽然在两种类型的癫痫活动期间涉及中央皮质,但脑电图(EEG) - 官能磁共振成像(FMRI)在焦点或广义放电时揭示了不同的神经网络,允许发电机的清晰分化。患者是否具有不同的癫痫综合征或来自损伤触发的不同的选举模式仍然是可扩张的。

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