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首页> 外文期刊>Epilepsy & behavior: E&B >Brain responses to auditory oddball task in children with benign childhood epilepsy with centrotemporal spikes: Quantitative analysis and correlation with neuropsychological assessment scores
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Brain responses to auditory oddball task in children with benign childhood epilepsy with centrotemporal spikes: Quantitative analysis and correlation with neuropsychological assessment scores

机译：脑响应良性儿童癫痫患儿的奇怪怪兽任务与中心峰值：定量分析和与神经心理学评估分数的相关性

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ObjectiveVariable degrees of cognitive dysfunction have been reported in children with benign childhood epilepsy with centrotemporal spikes (BCECTS). Our aim was to perform quantitative analyses of the brain responses to cognitive tasks using event-related desynchronization (ERD) and event-related synchronization (ERS) and correlating the results with the scores of neuropsychological tests in patients with BCECTS. MethodsThis case control study included 30 patients with BCECTS and 20 controls. Clinical assessment, neuropsychological tests, the Positive wave at 300 msec (P300) parameters recording, and quantitative electroencephalography (EEG) analysis were carried out for both groups. Alpha power ERD and ERS were measured in six different brain regions during an auditory oddball paradigm. ResultsChildren with epilepsy showed a statistically significant poorer performance in verbal intelligence quotient (IQ), performance IQ, and total scale IQ and lower number of correct responses. Moreover, both groups showed diffuse alpha power attenuation in response to the target tones. After summation of the alpha power ERD over all brain regions to get the net diffuse ERD, the patients' group showed a statistically significant smaller net alpha ERD compared with that of the control group (P=0.001). No significant correlations between the alpha ERD percentage, recorded P300 parameters, and neuropsychological tests scores were found. ConclusionsChildren with BCECTS have subtle cognitive dysfunction proved by significantly lower scores of verbal IQ and performance IQ subtests. The significantly smaller net diffuse alpha power ERD detected in children with epilepsy may be an electrophysiological indicator of disruptive brain activation in relation to cognitive attentional tasks; however, its correlation with neuropsychological tests was insignificant.
机译：良性儿童癫痫的儿童与Centrotemporal尖峰（BCects）的儿童报告了客观度认知功能障碍。我们的目的是使用事件相关的去同步（ERD）和事件相关的同步（ERS）来对大脑响应的定量分析和与事件相关的同步（ERS）相关，并将结果与​​BCCects患者的神经心理学测试的分数相关联。方法案例控制研究包括30名患有BCCects和20个对照的患者。对两个组进行临床评估，神经心理学测试，300毫秒（P300）参数记录和定量脑电图（EEG）分析的正波。在听觉奇怪的奇迹范式期间，在六个不同的大脑区域中测量了alpha功率ERD和ERS。癫痫患者在言语情报商（IQ），绩效智商和总级别IQ和较少数量的正确响应中显示出统计上显着的差的表现。此外，两组响应于目标音调显示弥漫性α功率衰减。在所有大脑区域的Alpha Power Erd的总结后，患者的弥漫性ERD，患者组与对照组的统计学显着的净αERD（P = 0.001）。没有发现αERD百分比，记录的P300参数与神经心理学测试分数之间没有显着相关性。结论具有BCects的含有微妙的认知功能障碍，通过显着降低了口头智商和表演智星性。在癫痫患儿中检测到的明显较小的净弥漫性α功率ERD可能是与认知注意力任务有关的破坏性脑激活的电生理指标;然而，它与神经心理学检测的相关性是微不足道的。

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