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首页> 外文期刊>Epidemiology >External Radiation Dose, Obesity, and Risk of Childhood Thyroid Cancer After the Fukushima Daiichi Nuclear Power Plant Accident: The Fukushima Health Management Survey
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External Radiation Dose, Obesity, and Risk of Childhood Thyroid Cancer After the Fukushima Daiichi Nuclear Power Plant Accident: The Fukushima Health Management Survey

机译：福岛Daiichi核电站事故后，外部辐射剂量，肥胖和儿童甲状腺癌的风险：福岛健康管理调查

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摘要

Background: The 2011 Great East Japan Earthquake led to a nuclear accident at Fukushima Daiichi Nuclear Power Plant. This study examines the associations of radiation dose and lifestyle factors with incidence of thyroid cancer in Fukushima. Methods: We designed a prospective study with 300,473 participants aged 18 years or younger, who underwent thyroid examinations from October 2011. Follow-up surveys were conducted through June 2017, and 245,530 participants (123,480 men and 122,050 women, 82% follow-up) received follow-up examinations. Fukushima Prefecture was divided into five areas based on individual external radiation dose. We calculated relative risks and 95% confidence intervals (CIs) for thyroid cancer in each area, with area of lowest dose as reference, using age-adjusted Poisson regression models. We also calculated risks associated with overweight and obesity. Results: The incidence per 100,000 for Groups A (highest dose), B, C, D, and E (lowest dose) were 13.5, 19.2, 17.3, 9.0, and 8.3, respectively. Compared with Group E, the age-adjusted risks (95% CIs) were 1.62 (0.59, 4.47) for group A, 2.32 (0.86, 6.24) for group B, 2.21 (0.82, 5.94) for group C, and 1.02 (0.36, 2.86) for group D. Obesity was positively associated with thyroid cancer incidence; the multivariable-adjusted risk of thyroid cancer was 2.23 (1.01, 4.90) for obese individuals compared with nonobese individuals. Conclusion: Regional differences in radiation dose were not associated with increased risk of thyroid cancer among children in Fukushima within 4 to 6 years after the nuclear power plant accident. Obesity may be an important factor for further follow-up in Fukushima.
机译：背景：2011年大东日本地震导致福岛帝茶核电站的核事故。本研究探讨了辐射剂量和生活方式因子与福岛甲状腺癌发病率的关联。方法：我们设计了一个预期的18岁或以下参与者的前瞻性研究，他们从2011年10月开始接受甲状腺检查。通过2017年6月进行后续调查，以及245,530名参与者（123,480名男性和122,050名女性，82％的后续行动）接受了后续检查。福岛县基于个体外部辐射剂量分为五个区域。我们计算每个区域的甲状腺癌的相对风险和95％置信区间（CIS），使用年龄调整后的泊松回归模型，具有最低剂量的面积。我们还计算出与超重和肥胖相关的风险。结果：每100,000组（最高剂量），B，C，D和E（最低剂量）的每10万次发病率分别为13.5,19.2,17.3,9.0和8.3。与E族相比，A组的A，2.32（0.86,6.24）的年龄调节的风险（95％CIS）为1.62（0.59,6.24），对于C组，2.21（0.82,5.94），1.02（0.36 2.86）对于D. D.肥胖与甲状腺癌发病率呈正相关;与非同一个人相比，肥胖个体的多变量调整的甲状腺癌风险为2.23（1.01,4.90）。结论：在核电站事故发生后4至6年内，辐射剂量的区域差异与福岛儿童的甲状腺癌的风险增加无关。肥胖可能是福岛进一步随访的重要因素。

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  • 来源
    《Epidemiology》 |2019年第6期|共8页
  • 作者

    Ohira Tetsuya; Ohtsuru Akira; Midorikawa Sanae; Takahashi Hideto; Yasumura Seiji; Suzuki Satoru; Matsuzuka Takashi; Shimura Hiroki; Ishikawa Tetsuo; Sakai Akira; Suzuki Shinichi; Yamashita Shunichi; Yokoya Susumu; Tanigawa Koichi; Ohto Hitoshi; Kamiya Kenji;

  • 作者单位

    Fukushima Med Univ Radiat Med Sci Ctr Fukushima Hlth Management Surv Fukushima Japan;

    Fukushima Med Univ Radiat Med Sci Ctr Fukushima Hlth Management Surv Fukushima Japan;

    Fukushima Med Univ Radiat Med Sci Ctr Fukushima Hlth Management Surv Fukushima Japan;

    Fukushima Med Univ Radiat Med Sci Ctr Fukushima Hlth Management Surv Fukushima Japan;

    Fukushima Med Univ Radiat Med Sci Ctr Fukushima Hlth Management Surv Fukushima Japan;

    Fukushima Med Univ Radiat Med Sci Ctr Fukushima Hlth Management Surv Fukushima Japan;

    Fukushima Med Univ Radiat Med Sci Ctr Fukushima Hlth Management Surv Fukushima Japan;

    Fukushima Med Univ Radiat Med Sci Ctr Fukushima Hlth Management Surv Fukushima Japan;

    Fukushima Med Univ Radiat Med Sci Ctr Fukushima Hlth Management Surv Fukushima Japan;

    Fukushima Med Univ Radiat Med Sci Ctr Fukushima Hlth Management Surv Fukushima Japan;

    Fukushima Med Univ Dept Thyroid &

    Endocrinol Sch Med Fukushima Japan;

    Fukushima Med Univ Radiat Med Sci Ctr Fukushima Hlth Management Surv Fukushima Japan;

    Fukushima Med Univ Radiat Med Sci Ctr Fukushima Hlth Management Surv Fukushima Japan;

    Fukushima Med Univ Radiat Med Sci Ctr Fukushima Hlth Management Surv Fukushima Japan;

    Fukushima Med Univ Radiat Med Sci Ctr Fukushima Hlth Management Surv Fukushima Japan;

    Fukushima Med Univ Radiat Med Sci Ctr Fukushima Hlth Management Surv Fukushima Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 流行病学与防疫;
  • 关键词

    Childhood; Disaster; Epidemiology; Population-based; Prospective study; Radiation; Thyroid gland;

    机译：童年;灾难;流行病学;基于人口;前瞻性研究;辐射;甲状腺;

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