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首页> 外文期刊>European Heart Journal: The Journal of the European Society of Cardiology >Epicardial fat and atrial fibrillation: current evidence, potential mechanisms, clinical implications, and future directions
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Epicardial fat and atrial fibrillation: current evidence, potential mechanisms, clinical implications, and future directions

机译：心外膜脂肪和心房颤动：当前证据，潜在机制，临床意义和未来方向

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摘要

Obesity is increasingly recognized as a major modifiable determinant of atrial fibrillation (AF). Although body mass index and other clinical measures are useful indications of general adiposity, much recent interest has focused on epicardial fat, a distinct adipose tissue depot that can be readily assessed using non-invasive imaging techniques. A growing body of data from epidemiological and clinical studies has demonstrated that epicardial fat is consistently associated with the presence, severity, and recurrence of AF across a range of clinical settings. Evidence from basic science and translational studies has also suggested that arrhythmogenic mechanisms may involve adipocyte infiltration, pro-fibrotic, and pro-inflammatory paracrine effects, oxidative stress, and other pathways. Despite these advances, however, significant uncertainty exists and many questions remain unanswered. In this article, we review our present understanding of epicardial fat, including its classification and quantification, existing evidence implicating its role in AF, potential mechanisms, implications for clinicians, and future directions for research.
机译：肥胖越来越被认为是心房颤动的主要可修饰的决定因素（AF）。虽然体重指数和其他临床措施是一般肥胖的有用指示，但最近的兴趣是专注于心外膜脂肪，一种不同的脂肪组织仓库，可以使用非侵入性成像技术容易地评估。流行病学和临床研究的越来越多的数据已经证明了心外膜脂肪与在一系列临床环境中的AF的存在，严重程度和复发始终如一。来自基础科学和翻译研究的证据还提出了脑心血性机制可能涉及脂肪细胞浸润，促纤维化和促炎旁静脉作用，氧化应激和其他途径。然而，尽管这些进步，但存在重大不确定性，并且许多问题仍未得到答复。在本文中，我们审查了我们对表皮脂肪的现有理解，包括其分类和量化，现有证据暗示其在AF，潜在机制，对临床医生的影响以及未来的研究方向的作用。

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