...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Sex and gender differences in Alzheimer’s disease: current challenges and implications for clinical practice
【24h】

Sex and gender differences in Alzheimer’s disease: current challenges and implications for clinical practice

机译：阿尔茨海默病的性别和性别差异：目前对临床实践的挑战和影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Alzheimer’s disease (AD) is characterized by high heterogeneity in disease manifestation, progression and risk factors. High phenotypic variability is currently regarded as one of the largest hurdles in early diagnosis and in the design of clinical trials; there is therefore great interest in identifying factors driving variability that can be used for patient stratification. In addition to genetic and lifestyle factors, the individual’s sex and gender are emerging as crucial drivers of phenotypic variability. Evidence exists on sex and gender differences in the rate of cognitive deterioration and brain atrophy, and in the effect of risk factors as well as in the patterns of diagnostic biomarkers. Such evidence might be of high relevance and requires attention in clinical practice and clinical trials. However, sex and gender differences are currently seldom appreciated; importantly, consideration of sex and gender differences is not currently a focus in the design and analysis of clinical trials for AD. The objective of this position paper is (i) to provide an overview of known sex and gender differences that might have implications for clinical practice, (ii) to identify the most important knowledge gaps in the field (with a special regard to clinical trials) and (iii) to provide conclusions for future studies. This scientific statement is endorsed by the European Academy of Neurology.
机译：阿尔茨海默病（AD）的特点是疾病表现，进展和危险因素的高异质性。目前，高表型变异性被认为是早期诊断和临床试验设计中最大的障碍之一;因此，对促进可用于患者分层的因素的因素具有很大的兴趣。除了遗传和生活方式因素之外，个人的性别和性别是作为表型变异性的关键驱动因素。性别和性别差异存在于认知恶化和脑萎缩的性别差异，以及危险因素以及诊断生物标志物模式的影响。这些证据可能具有高相关性，需要注意临床实践和临床试验。但是，目前性别和性别差异目前很少受到赞赏;重要的是，审议性别和性别差异目前尚未侧重于对广告的临床试验的设计和分析。该立场文件的目的是（i）概述，概述可能对临床实践有影响，（ii）识别该领域最重要的知识差距（具有特别考虑临床试验） （iii）为未来的研究提供结论。该科学陈述是由欧洲神经科学院的认可。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号