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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Contingent negative variation: a biomarker of abnormal attention in functional movement disorders
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Contingent negative variation: a biomarker of abnormal attention in functional movement disorders

机译：或有负面变异：功能运动障碍中异常关注的生物标志物

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Background and purpose Contingent negative variation (CNV) is a negative cortical wave that precedes a pre‐cued imperative stimulus requiring a quick motor response. It has been related to motor preparation and anticipatory attention. The aim was to ascertain whether the clinical improvement of functional movement disorders after physiotherapy would be associated with faster reaction times and modulation of CNV. Methods Motor performance and CNV were analysed during a pre‐cued choice reaction time task with varying cue validity. Twenty‐one patients with functional movement disorders and 13 healthy controls at baseline were compared. Patients then underwent physiotherapy. At follow‐up after physiotherapy, patients were categorized as clinically improved (responders) or not improved (non‐responders) and retested. Results At baseline, patients did not generate CNV, contrary to controls [mean amplitude (μV) at the end of preparation to move: patients ?0.47 (95% CI ?1.94, 1.00) versus controls ?2.59 (95% CI ?4.46, ?0.72)]. Responders performed faster after physiotherapy [mean natural logarithm?(ln) reaction time (RT)?(ms): follow‐up 6.112 (95% CI 5.923, 6.301) versus baseline 6.206 (95% CI 6.019, 6.394), P = 0.010], contrary to non‐responders. Simultaneously, responders showed a recovery of CNV after physiotherapy [follow‐up ?1.95 (95% CI ?3.49, ?0.41) versus baseline ?0.19 (95% CI ?1.73, 1.35), P ??0.001], contrary to non‐responders [follow‐up ?0.32 (95% CI ?1.79, 1.14) versus baseline ?0.72 (95% CI ?2.19, 0.75), P = 0.381]. Conclusions Clinical improvement of functional movement disorders after physiotherapy was associated with faster reaction times and normalization of CNV, which was absent at baseline. These findings suggest that CNV may constitute a useful neurophysiological biomarker related to abnormal attention in functional movement disorders.
机译：背景和目的或目的的消毒负变化（CNV）是一种负皮波，其前面需要快速电动机响应的预先提高的诱导刺激。它与电机准备和预期关注有关。目的是确定物理疗法后功能运动障碍的临床改善是否会与CNV更快的反应时间和调节相关。方法在具有不同提示有效性的预热选择反应时间任务期间分析电机性能和CNV。比较了二十一名患有功能性运动障碍的患者和13个基线健康对照。然后患者接受了物理治疗。在物理治疗后随访时，患者被分类为临床改善（响应者）或未改善（非响应者）并重新测试。结果在基线，患者没有产生CNV，与对照组相反？0.72）]。响应者在物理治疗后更快地进行[平均自然对数吗？（LN）反应时间（RT）？（MS）：随访6.112（95％CI 5.923,6.301）与基线6.206（95％CI 6.019,6.394），P = 0.010 ]，与非响应者相反。同时，响应者在物理疗法后恢复了CNV [后续？1.95（95％CI？3.49，？0.41）与基线？0.19（95％CI？1.73,1.35），P？＆？0.001]，相反非响应者[后续？0.32（95％CI？1.79,1.14）与基线？0.72（95％CI？2.19,0.75），P = 0.381]。结论物理疗法后功能运动障碍的临床改善与基线不存在的CNV反应时间和CNV的标准化相关。这些发现表明CNV可以构成有用的神经生理学生物标志物，其与功能性运动障碍的异常关注有关。

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