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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Respiratory function and cognitive profile in amyotrophic lateral sclerosis
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Respiratory function and cognitive profile in amyotrophic lateral sclerosis

机译：肌营养侧面硬化症中的呼吸功能和认知概况

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Background and purpose Amyotrophic lateral sclerosis (ALS) is increasingly recognized as a multisystem disorder with 30%–50% of patients exhibiting cognitive impairment. The pathophysiological mechanisms of cognitive dysfunction are probably multifactorial although hypoventilation secondary to respiratory dysfunction may contribute to cognitive decline. The current study aimed to identify the relationship between respiratory function in ALS patients and the presence and degree of cognitive impairment. Methods Amyotrophic lateral sclerosis patients were prospectively recruited from a multidisciplinary ALS clinic. Baseline clinical assessments including respiratory function as assessed by spirometry were recorded with forced vital capacity (FVC) ≤ 75% considered to be reduced respiratory function. Cognitive testing was performed utilizing the Addenbrooke’s Cognitive Examination (ACE) and the Mini‐Mental State Examination (MMSE). Results From a cohort of 100 ALS patients, 48% were categorized as having impaired respiratory function (FVC?=?58.24%?±?2.15%) whilst 52% had normal function (88.65%?±?1.27%). Compared to the group with normal respiratory function (ACE 90.68 ± 0.89, MMSE 28.22 ± 0.21), patients with respiratory dysfunction had significantly reduced cognitive function (ACE 86.83?± 1.5, P ?=?0.025; MMSE 26.29?± 0.45, P ?=?0.029). Furthermore, subscores demonstrated significant differences between the groups with respect to domains in memory ( P ?=?0.003) and attention ( P ?=?0.05) with a trend observed in fluency ( P ?=?0.082). There was a significant correlation between patient baseline FVC and ACE scores as well as between FVC and memory and fluency subscores ( P ??0.01). Conclusion Amyotrophic lateral sclerosis patients with respiratory compromise were more likely to develop reduced cognitive function. In addition to improving physical function, it remains plausible that non‐invasive ventilation may alter the progression of cognitive impairment in ALS patients and potentially improve overall quality of life and carer burden.
机译：背景和目的肌萎缩侧面硬化症（ALS）越来越被认为是具有表现成认知障碍的30％-50％的多系统障碍。认知功能障碍的病理生理机制可能是多因素，尽管继发于呼吸功能障碍的下呼吸悬浮可能有助于认知下降。目前的研究旨在识别ALS患者呼吸功能与认知障碍的存在和程度的关系。方法从多学科ALS诊所潜在招募肌萎缩侧颅骨菌病患者。基线临床评估，包括肺活量测定评估的呼吸功能，用强烈的生气能力（FVC）≤75％被认为是降低呼吸功能。使用addenbroke的认知检查（ACE）和迷你精神状态检查（MMSE）进行认知测试。 100 Als患者的队列的结果，48％被分类为呼吸功能受损（FVC？=α= 58.24％？±2.15％），而52％具有正常功能（88.65％？±1.27％）。与具有正常呼吸功能的组相比（ACE 90.68±0.89，MMSE 28.22±0.21），呼吸功能障碍的患者具有显着降低的认知功能（ACE 86.83？±1.5，P？= 0.025; MMS 26.29？±0.45，P？ =？0.029）。此外，子群体在内存中的结构域（p？= 0.003）和注意力（p？= 0.05）中展示了群体之间的显着差异（p？= 0.05），趋势（p？= 0.082）。患者基线FVC和ACE评分以及FVC和内存和流畅性亚克之间存在显着相关性（P？＆？0.01）。结论患有呼吸折衷的肌萎缩侧颅骨菌病患者更有可能产生减少的认知功能。除了改善物理功能外，仍然可以合理于，非侵入性通风可能会改变ALS患者的认知障碍的进展，并潜在地提高生活质量和护理负担。

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