...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Identification of a predominant cognitive phenotype in patients with multiple sclerosis
【24h】

Identification of a predominant cognitive phenotype in patients with multiple sclerosis

机译：鉴定多发性硬化症患者的主要认知表型

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background and purpose Cognitive impairment occurs frequently in multiple sclerosis (MS). However, the prevalence and clinical characteristics of cognitive MS phenotype are not well established. The aim of the study was to characterize the clinical course and neurocognitive impairment of patients with MS meeting an Expanded Disability Status Scale (EDSS)‐defined cognitive phenotype. Methods A total of 2302 patients from the Comprehensive Longitudinal Investigation of Multiple Sclerosis at Brigham and Women’s Hospital (CLIMB) study were studied. Predominant cognitive MS phenotype was defined as EDSS Cerebral Functional System (FS) subscore ≥3 and remaining EDSS FS subscores ≤2 on at least one clinical visit. Demographic/clinical characteristics, phenotype stability and neurocognitive domain impairment of these subjects were assessed. Results A total of 60 of 2302 (2.6%) patients (age 52.8?±?10.8?years, 68% female, 82% relapsing MS) met criteria for phenotype designation. A total of 29 of 60 (48%) were designated within 10?years of their presenting MS symptom. The mean cohort annualized relapse rate was 0.38 and EDSS score at last clinical assessment was 3.2?±?1.3. Cognitive phenotype status was poorly sustained, with only 27% of subjects maintaining Cerebral FS score ≥2 throughout all follow‐up. However, predominant cognitive phenotype subjects with clinical neuropsychiatric testing [ n ?=?39/60 (65%)] frequently had cognitive impairment (1.5 SD below mean) in ≥1 domain [ n ?=?30/39 (77%) of subjects] affecting memory, attention/executive function and processing speed. A total of 11 of 39 (28%) patients had severe‐range cognitive impairment (3.0 SD below mean). Cognitive phenotype designation was associated with low rate of employment at last clinical assessment. Conclusion Predominant cognitive MS phenotype is rare, although an EDSS‐based definition identifies patients with multidomain cognitive impairment and may serve as a practical screen for identification of patients who might warrant close monitoring of neurocognitive status.
机译：背景和目的的认知障碍经常发生在多发性硬化（MS）中。然而，认知MS表型的患病率和临床特征不是很好的。该研究的目的是表征临床过程和MS患者的临床过程和神经认知损伤，所述MS患者达到扩大的残疾状态规模（EDSS） - 定义的认知表型。方法研究了5302例患有来自Brigham和女性医院（攀登）研究的多发性硬化综合性纵向调查的患者。主要的认知MS表型被定义为EDSS脑功能系统（FS）患者≥3，并且在至少一个临床访问中剩余EDSS FS≤2。评估了这些受试者的人口统计/临床特征，表型稳定性和神经认知域损伤。结果总共602例（2.6％）患者（2.6％）（52.8岁？±10.8岁，68％的女性，82％复发MS）符合表型指定的标准。总共29个（48％）在其呈现MS症状的10年内指定。平均裁员年化复发率为0.38，最后临床评估的EDSS评分为3.2？±1.3。认知表型状态持续不良，只有27％的受试者在所有随访中保持脑FS得分≥2。然而，主要的认知表型受试者具有临床神经精神测试[n吗？= 39/60（65％）]经常在≥1结构域中的认知障碍（1.5 sd以下平均值）[n吗？30/39（77％）受试者]影响内存，注意力/执行功能和处理速度。共有39名（28％）患者共有11个患者的严重程度认知障碍（3.0 SD以下平均值）。认知表型指定在最后的临床评估中与低的就业率有关。结论主要认知MS表型是罕见的，尽管基于EDSS的定义鉴定了多畴认知障碍的患者，可作为鉴定可能保证患者的实际筛查，以便密切监测神经认知状态。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号