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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Urinalysis in patients with neuromyelitis optica spectrum disorder
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Urinalysis in patients with neuromyelitis optica spectrum disorder

机译：神经肌炎OPTICA谱系患者尿液分析

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Background and purpose Increasing evidence has demonstrated that aquaporin‐4 (AQP4) immunoglobulin G causes damage to the kidney in neuromyelitis optica spectrum disorder (NMOSD). However, changes in urinalysis in NMOSD have not been investigated thus far. Our objective was to evaluate the changes in urinalysis in NMOSD patients. Methods Case data were collected from 44 patients with AQP4 antibody‐positive NMOSD, 53 patients with multiple sclerosis (MS) and 79 age‐ and sex‐matched healthy controls. Analyses of early morning urine and 24‐h urine samples comparing NMOSD with MS patients were conducted. Results In the acute phase, urine pH levels ( P ??0.001) and urine specific gravity levels ( P ??0.001) from NMOSD patients were significantly higher and lower, respectively, than for MS patients. 24‐h urine sodium and 24‐h urine volume from NMOSD patients were significantly higher than for MS patients (both P ?=?0.001). A 24‐h urine volume higher than 2500?ml (odds ratio 11.7, 95% confidence interval 1.863–73.066) and a 24‐h urine sodium higher than 200?mmol (odds ratio 16.0, 95% confidence interval 2.122–120.648) are more likely to occur in NMOSD patients in the acute phase than in MS patients. Conclusions The urinalysis results were significantly different between NMOSD patients and MS patients. The pathophysiological changes in AQP4 antibody‐positive NMOSD patients were not limited to the central nervous system.
机译：背景和目的越来越多的证据证明了Aquaporin-4（AQP4）免疫球蛋白G对神经肌炎Optica谱系疾病（NMOSD）的肾脏造成伤害。然而，迄今为止尚未调查NMOSD中尿液分析的变化。我们的目标是评估NMOSD患者尿液分析的变化。方法从44例AQP4抗体阳性NMOSD患者中收集案例数据，53例多发性硬化症（MS）和79岁和性别匹配的健康对照。对与MS患者进行乳腺癌的清晨尿液和24小时尿液样本的分析进行进行。导致急性相，尿pH水平（p≤≤0.001）和来自NMOSD患者的尿液比重水平和尿液比重分别比对于MS患者显着提高和更低。来自NMOSD患者的24小时尿钠和24-H尿量显着高于MS患者（P？= 0.001）。 24-h尿体积高于2500？ml（差距11.7,95％置信区间1.863-73.066）和高于200？mmol的24-h尿液钠（差距16.0,95％置信区间2.122-120.648）是更有可能在急性期患者中发生的患者比MS患者。结论NMOSD患者和MS患者之间的尿液分析结果显着差异。 AQP4抗体阳性NMOSD患者的病理生理变化不限于中枢神经系统。

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