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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Grey matter abnormalities in Parkinson’s disease: a voxel‐wise meta‐analysis
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Grey matter abnormalities in Parkinson’s disease: a voxel‐wise meta‐analysis

机译：帕金森病的灰质异常：Voxel-Wise Meta分析

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Background and purpose The pathophysiology of Parkinson’s disease (PD) remains unclear. Voxel‐based morphometry (VBM) detects local structural differences in brain tissue such as grey matter volume (GMV) between groups, which is helpful in understanding the pathophysiology of PD. Published VBM studies of GMV changes in PD have shown inconsistent results. Therefore, a voxel‐wise meta‐analysis of VBM studies was conducted to detect consistent GMV changes in PD. Methods The published literature was searched comparing whole‐brain GMV between PD patients and healthy controls (HCs) using VBM. Coordinates were extracted for the clusters of significant GMV differences between PD patients and HCs. The meta‐analysis was performed by seed‐based d mapping software. Results A total of 63 studies with 2867 PD patients and 1990 HCs were included. Significant GMV reductions in some brain regions were detected in PD patients, which were involved in the basal ganglia, theory of mind, vocal and visual networks. These findings remained largely unchanged in the jackknife sensitivity analysis, and no significant heterogeneity or publication bias was detected. Conclusions Parkinson’s disease patients have GMV reductions in a number of brain regions involved in specific networks. These findings provide morphological evidence for the pathophysiology of PD.
机译：背景和目的帕金森病（PD）的病理生理学仍然不清楚。基于体的形态（VBM）检测脑组织（如组）之间的脑组织局部结构差异，这有助于理解PD的病理生理学。已发布的VBM研究PD的GMV变化显示结果不一致。因此，进行了VBM研究的体素 - 明智的Meta分析以检测Pd的一致GMV变化。方法使用VBM对PD患者和健康对照（HCS）之间的全脑GMV进行搜索的出版文献。提取坐标，用于PD患者和HCS之间的显着GMV差异的簇。通过基于种子的D映射软件进行META分析。结果共有63项患有2867名PD患者和1990 HCS的研究。在PD患者中检测到一些大脑区域的重大GMV减少，这些患者涉及基础神经节，心灵理论，声乐和视觉网络。这些发现在巨石敏感性分析中仍然很大程度地保持不变，并且没有检测到显着的异质性或出版物偏差。结论帕金森病患者的疾病患者在涉及特定网络的许多大脑区域中有GMV减少。这些发现提供了PD病理生理学的形态学证据。

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