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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Oxidative stress, inflammation and risk of neurodegeneration in a population sample
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Oxidative stress, inflammation and risk of neurodegeneration in a population sample

机译：氧化应激，血肿中的肿瘤炎症和群体样本中神经变性的风险

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Background and purpose Inflammation and oxidative stress (OS) have been clearly linked to neurodegeneration. However, studies investigating the associations between peripheral markers of inflammation and cognitive decline have produced mixed results. This is possibly due to the fact that markers are typically tested individually despite the fact that biologically they function interactively. Thus, the aim of this study was to investigate the association between a combination of OS/inflammation markers and outcomes including mild cognitive impairment (MCI) diagnosis, cognitive decline and hippocampal atrophy. Methods Oxidative stress/inflammation status was assessed in 380 older community‐living individuals. Thirteen blood markers were assayed. Principal component analysis (PCA) of all markers was conducted to identify the more salient inflammatory components. Associations between significant principal components, MCI diagnosis, previous change in Mini‐Mental State Examination (MMSE) score and hippocampal atrophy were investigated through logistic and linear multiple regression. Results Two factors (PC1 and PC2) reflecting predominantly broad pro‐inflammatory activity and two factors (PC3 and PC4) reflecting predominantly OS activity were identified by PCA analysis. PC3 and PC4 were predictive of MCI. PC3 was also predictive of prior MMSE change. PC1, PC2 and PC3 were significantly associated with hippocampal atrophy. Conclusions Combined analysis of complex and interacting biomarkers revealed a protective association between antioxidant activity and MCI that is consistent with lifestyle factors shown to reduce risk of cognitive decline. OS and broad systemic inflammation were also found to be associated with hippocampal atrophy further highlighting the benefits of the PCA methodology applied in this study.
机译：背景和目的炎症和氧化应激（OS）已与神经变性显然。然而，研究调查炎症和认知下降的外周标志物之间的关联产生了混合结果。这可能是因为，尽管在可以交互地运作的事实，但是标记通常是单独测试的。因此，本研究的目的是探讨OS /炎症标志物和结果组合之间的关联，包括轻度认知障碍（MCI）诊断，认知下降和海马萎缩。方法在380名较旧的社区生活中评估氧化应激/炎症状态。测定十三个血迹。进行所有标记的主成分分析（PCA）以鉴定更突出的炎症组分。通过逻辑和线性多元回归研究了重要的主要成分，MCI诊断，先前改变迷你精神状态检查（MMSE）评分和海马萎缩之间的关联。结果通过PCA分析鉴定了反映了主要宽炎症活动的两个因素（PC1和PC2）反映了主要反射OS活性的两个因素（PC3和PC4）。 PC3和PC4预测MCI。 PC3也预测了先前MMSE变化。 PC1，PC2和PC3与海马萎缩有显着相关。结论复合物和互动生物标志物的组合分析显示抗氧化活性与MCI之间的保护关系，这是与显现的生活方式因子一致，以降低认知衰退的风险。还发现OS和广泛的全身炎症与海马萎缩有关，进一步突出了本研究中应用的PCA方法的益处。

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