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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Toronto Clinical Neuropathy Score is valid for a wide spectrum of polyneuropathies
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Toronto Clinical Neuropathy Score is valid for a wide spectrum of polyneuropathies

机译：多伦多临床神经病变评分对于广泛的多种多变疗法有效

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Background and purpose The Toronto Clinical Neuropathy Score ( TCNS ) is a valid and reliable scale for the diagnosis and staging of diabetic sensorimotor polyneuropathy. In this study, we aimed to explore the performance of the TCNS in non‐diabetic polyneuropathies. Methods We performed a prospective study from November 2016 to May 2017 of patients with non‐diabetic polyneuropathy. Patients had clinical, electrophysiological and functional assessments of their polyneuropathy, and the findings were correlated with the TCNS . Results The TCNS correlated with all clinical, electrophysiological and disability measures of polyneuropathy, mostly at a moderate level (e.g. r = ?0.58 for sural nerve action potential amplitude). Higher TCNS severity grades were associated with worse polyneuropathy on all measures in the lower limbs, and with worse electrophysiological parameters and vibration perception thresholds in the upper limbs. The scale also showed excellent reliability and accuracy (kappa, 0.92–0.93 for inter‐ and intra‐observer reliability; area under the receiver operating characteristics curve, 0.93). Conclusion The TCNS is a valid and reliable scale for a wide spectrum of polyneuropathies, and might be useful in clinical practise and research for the diagnosis and staging of polyneuropathy.
机译：背景和目的多伦多临床神经病评分（TCNS）是糖尿病感觉传感器多变病变的诊断和分期的有效且可靠的规模。在这项研究中，我们的目标是探讨TCNS在非糖尿病多洋药片中的表现。方法采用2016年11月至2017年5月进行了非糖尿病多肺病变的患者进行了前瞻性研究。患者对其变性病变具有临床，电生理学和功能性评估，并且研究结果与TCN相关。结果TCN与所有临床，电生理和残疾措施相关的多种水肿，主要是在适度水平（例如，避免血管神经动作电位幅度的0.58）。较高的TCNS严重程度与下肢的所有措施更差，并且上肢中的电生理参数和振动感知阈值更差。规模还显示出优异的可靠性和准确性（Kappa，0.92-0.93，用于观察间的可靠性和内部观察者可靠性;接收器操作特性曲线下的区域为0.93）。结论TCNS是一种有效且可靠的尺度，可用于广谱的多光谱，并且可用于临床实践和研究对多肺病的诊断和分期。

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