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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Association between β‐cell function estimated by HOMA HOMA ‐β and prognosis of non‐diabetic patients with ischaemic stroke
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Association between β‐cell function estimated by HOMA HOMA ‐β and prognosis of non‐diabetic patients with ischaemic stroke

机译：HOMA HOMA-β估计的β细胞功能与缺血性卒中非糖尿病患者的预后的关系

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Background and purpose Studies showed that β‐cell dysfunction is associated with increased risk of cardiovascular disease and subclinical carotid atherosclerosis. This study aimed to investigate the association between β‐cell function and prognosis of non‐diabetic patients with ischaemic stroke. Methods Ischaemic stroke patients without diabetes in the Abnormal Glucose Regulation in Patients with Acute Stroke across China registry were included in this analysis. Homeostasis assessment of β‐cell function ( HOMA ‐β) was performed and classified into four groups according to quartiles. The outcomes included stroke recurrence, poor functional outcome and all‐cause mortality. Results In a total of 1244 patients, the average age was 62.3?years; 63.1% patients were male. At 1 year, the first quartile of HOMA ‐β (54.0) was associated with increased stroke recurrence (adjusted hazard ratio 2.04, 95% confidence interval 1.32–3.17, P? = ? 0.001), poor functional outcome (adjusted odds ratio 3.04, 95% confidence interval 1.90–4.88, P? ? 0.001) and mortality (adjusted hazard ratio 4.12, 95% confidence interval 2.24?7.59, P? ? 0.001) compared with the fourth quartile of HOMA ‐β (≥166.3) after adjustment for insulin resistance and other potential covariates. The second and third quartiles of HOMA ‐β were significantly associated with an increased risk of poor functional outcome. Multivariable regression analysis with restricted cubic splines showed an L‐shaped association between HOMA ‐β and outcomes at 1?year. Conclusions Our study shows that lower HOMA ‐β level is associated with poor outcomes at 1?year in non‐diabetic patients with ischaemic stroke.
机译：背景和目的研究表明，β-细胞功能障碍与心血管疾病和亚临床颈动脉粥样硬化的风险增加有关。本研究旨在探讨缺血性脑卒中非糖尿病患者β细胞功能与预后的关联。方法缺血中风患者在中国注册表中急性中风患者的异常葡萄糖调节中的患者均包含在此分析中。根据四分位数进行β细胞功能（HOMA-β）的稳态评估并分为四组。结果包括卒中复发，功能性差异差和全导致死亡率。结果共有1244名患者，平均年龄为62.3岁以下时间; 63.1％的患者是男性。在1年后，HOMA-β（＆LT; 54.0）的第一个四分位数与卒中复发增加有关（调整后危险比2.04,95％置信区间1.32-3.17，p？= 0.001），功能结果不良（调整赔率比3.04,95％置信区间1.90-4.88，p？<0.001）和死亡率（调节危险比4.12,95％置信区间2.24？7.59，P≤2.<0.001）与HOMA-β（ ≥166.3）调整胰岛素抵抗和其他潜在的协变量。 HOMA-β的第二个和第三个四分位数与功能性差的结果的风险增加显着相关。具有受限制立方样条的多变量回归分析显示HOMA-β与1年的结果之间的L形关联。结论我们的研究表明，较低的HOMA-β水平与缺血性卒中的非糖尿病患者的1岁的结果差。

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