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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Potential indications for deep brain stimulation in neurological disorders: an evolving field
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Potential indications for deep brain stimulation in neurological disorders: an evolving field

机译：神经障碍深脑刺激的潜在适应症：一种不断发展的田地

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Deep brain stimulation ( DBS ) is an established therapy for appropriately selected patients with movement disorders and neuropsychiatric conditions. Although the exact mechanisms and biology of DBS are not fully understood, it is a safe and well‐tolerated therapy for many refractory cases of neuropsychiatric disease. Increasingly, DBS has been explored in other conditions with encouraging results. In this paper, available data is reviewed and new DBS targets, challenges and future directions in neurological disorders are explored. A detailed search of the medical literature discussing the potential use of DBS for neurological disorders excluding accepted indications was conducted. All reports were analyzed individually for content and redundant articles were excluded by examining individual abstracts. The level of evidence for each indication was summarized. Multiple studies report promising preliminary data regarding the safety and efficacy of DBS for a variety of neurological indications including chronic pain, tinnitus, epilepsy, Tourette syndrome, Huntington's disease, tardive dyskinesia and Alzheimer's disease. The initial results of DBS studies for diverse neurological disorders are encouraging but larger, controlled, prospective, homogeneous clinical trials are necessary to establish long‐term safety and effectiveness. The field of neuromodulation continues to evolve and advances in DBS technology, stereotactic techniques, neuroimaging and DBS programming capabilities are shaping the present and future of DBS research and use in practice.
机译：Deep brain stimulation ( DBS ) is an established therapy for appropriately selected patients with movement disorders and neuropsychiatric conditions.虽然DBS的确切机制和生物学尚未完全明白，但对于许多神经精神疾病的难治性案例是一种安全且耐受性的耐受性。越来越多地，DBS已经在其他条件下探讨了令人鼓舞的结果。在本文中，探讨了可用数据，并探讨了神经系统障碍中的新DBS目标，挑战和未来方向。对医学文献进行了详细的搜索，讨论了除了不包括接受的适应症的神经系统疾病的潜在使用DBS的潜在使用。所有报告都单独分析以进行内容，并通过检查单个摘要排除冗余物品。总结了每个指示的证据水平。多项研究报告了关于DBS的各种神经功能的安全性和疗效的初步数据，包括慢性疼痛，耳鸣，癫痫，Tourette综合征，Huntington的疾病，迟钝的吞吐瘤和阿尔茨海默病。 DBS研究对多种神经系统疾病的初始结果令人鼓舞，但较大，控制，前瞻性，均匀的临床试验是建立长期安全性和有效性的必要条件。神经调节领域继续发展，DBS技术，立体定向技术，神经影像学和DBS编程能力正在塑造DBS研究和在实践中使用的现状和未来。

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