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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Non‐alcoholic fatty liver disease is associated with stroke severity and progression of brainstem infarctions
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Non‐alcoholic fatty liver disease is associated with stroke severity and progression of brainstem infarctions

机译：非酒精性脂肪肝病与中风严重程度和脑干梗塞的进展有关

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Background and purpose Non‐alcoholic fatty liver disease ( NAFLD ) is closely correlated to visceral obesity, dyslipidaemia, insulin resistance and type 2 diabetes mellitus. We sought to assess the association between a specific stroke subgroup, brainstem infarctions ( BSI s) and NAFLD . Furthermore, we evaluated whether NAFLD is an independent risk factor in patients with BSI s. Methods Non‐alcoholic fatty liver disease was assessed in 306 patients with radiologically confirmed BSI s via liver ultrasound. Differences between patients with and without NAFLD were compared. Data associated with stroke severity and progression after admission were collected. Results Non‐alcoholic fatty liver disease was found in 130 (42.5%) patients with acute BSI s; 58 (19.0%) had National Institutes of Health Stroke Scale scores 7 and 57 (18.6%) had progression after admission. Initial National Institutes of Health Stroke Scale scores, incidence of progression and stroke severity, and modified Rankin Scale scores at discharge were significantly higher in patients with NAFLD than in those without NAFLD . NAFLD was associated with stroke severity [Cox regression: hazard ratio ( HR ), 2.243; 95% confidence interval ( CI ), 1.254–4.013, P 0.01]. This risk remained statistically significant after controlling for age, gender, diabetes mellitus and C‐reactive protein ( HR , 2.327; 95% CI , 1.252–4.324, P 0.01). In addition, NAFLD was associated with progression ( HR , 2.155; 95% CI , 1.201–3.865, P 0.05) and remained significant after controlling for age, gender, diabetes mellitus, fibrinogen and C‐reactive protein ( HR , 2.378; 95% CI , 1.260–4.486, P 0.01). Conclusions These results suggest that NAFLD is a potential risk factor when evaluating the severity and progression of acute BSI s. This relationship is independent of classic risk factors and metabolic syndrome features.
机译：背景和目的非酒精性脂肪肝病（NAFLD）与内脏肥胖，血脂血症，胰岛素抵抗和2型糖尿病密切相关。我们试图评估特定中风亚组，脑干梗塞（BSI S）和NAFLD之间的关联。此外，我们评估了NAFLD是否是BSI S患者的独立危险因素。方法在306例肝脏超声中，在306例放射学证实BSI S中评估非酒精脂肪肝疾病。比较了没有NAFLD患者的差异。收集了与中风严重程度和进展相关的数据。结果在130名（42.5％）急性BSI S患者中发现了非酒精性脂肪肝病; 58（19.0％）已有国家卫生卒中规模评分＆ 7和57（18.6％）入院后的进展。初步国家健康冲程量表评分，进展发病和中风严重程度，并且在NAFLD患者中，在没有NAFLD的那些中，放电的改良Rankin规模分数显着高。 NAFLD与行程严重程度相关[COX回归：危险比（HR），2.243; 95％置信区间（CI），1.254-4.013，P＆ 0.01]在控制年龄，性别，糖尿病和C反应蛋白（HR，2.327; 95％CI，1.252-4.324，P＆LT; 0.01）后，这种风险仍然存在统计学意义。此外，NAFLD与进展相关（HR，2.155; 95％CI，1.201-3.865，P＆ 0.05），并在控制年龄，性别，糖尿病，纤维蛋白原和C反应蛋白（HR，2.378; 95％CI，1.260-4.486，P <0.01）。结论这些结果表明，当评估急性BSI S的严重程度和进展时，NAFLD是一种潜在的危险因素。这种关系与经典风险因素和代谢综合征特征无关。

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