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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Low‐dose rescue tirofiban in mechanical thrombectomy for acute cerebral large‐artery occlusion
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Low‐dose rescue tirofiban in mechanical thrombectomy for acute cerebral large‐artery occlusion

机译：低剂量拯救急性脑大动脉闭塞机械血栓切除术

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Background and purpose Tirofiban administration during mechanical thrombectomy (MT) remains controversial. The aim was to evaluate the safety and efficacy of a low‐dose rescue tirofiban regimen during MT for Chinese acute ischaemic stroke (AIS) patients. Methods Patients from the ANGEL study, a multicentric, prospective registry study that included AIS patients who underwent MT owing to proximal large‐artery occlusion from June 2015 to December 2017, were collected. The patients were dichotomized into tirofiban and non‐tirofiban groups according to whether rescue tirofiban was performed during MT. Safety outcomes [symptomatic intracerebral haemorrhage (sICH), total intracerebral haemorrhage (ICH) and distal embolization] and efficacy outcomes (artery recanalization and functional outcomes at 3‐month follow‐up) were compared between groups using logistic regression analysis. Results A total of 662 patients were included in this study, and 230 (34.7%) were in the tirofiban group. No significant differences in safety outcomes on sICH, total ICH and distal embolization and efficacy outcomes on artery recanalization and 3‐month functional independence were observed between the tirofiban and non‐tirofiban group in the entire cohort or the anterior circulation stroke or posterior circulation stroke patients ( P? ?0.05 for all groups). However, low‐dose rescue tirofiban was significantly correlated with 3‐month mortality reduction for posterior circulation stroke patients [adjusted hazard ratio?0.35 (0.14–0.92), P ?=?0.03]. Conclusions Low‐dose rescue tirofiban during MT was not associated with increased risk of sICH, ICH and distal embolization for AIS patients, and may be correlated with 3‐month mortality reduction for posterior circulation stroke.
机译：背景和目的在机械血栓切除术期间的促替贝班管理仍然存在争议。目的是评估低剂量救援促毛利布方案的安全性和疗效在MT中用于中国急性缺血性卒中（AIS）患者。方法采用天使研究的患者，包括从2015年6月到2017年6月从2017年6月到2017年12月的近端大动脉闭塞的AIS患者的多中心预期登记研究。根据在MT期间是否进行抢救促苏福兰，患者将患者分成二分溶于替洛菲班和非替托巴纳。在使用Logistic回归分析之间比较了安全结果[症状性脑血管出血（SICH），总脑内出血（ICH）和远端栓塞，疗效结果（3个月随访中的动脉重新化和功能结果）。结果本研究共有662名患者，230名（34.7％）在替洛菲班组。在整个队列或前循环中风或后循环中风或后循环中风患者中，观察到在整个队列或前循环中风患者的替洛菲比班和非促六班组之间存在显着差异。 （p？＆Δ05，适用于所有群体）。然而，低剂量抢救促乳蛋白与后循环中风患者的3个月死亡率显着相关[调整危险比吗？0.35（0.14-0.92），p？= 0.03]。结论MT期间的低剂量救援促血布与AIS患者的SICH，ICH和远端栓塞的风险增加无关，可能与后循环中风的3个月死亡率降低相关。

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