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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Cholinergic denervation in patients with idiopathic rapid eye movement sleep behaviour disorder
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Cholinergic denervation in patients with idiopathic rapid eye movement sleep behaviour disorder

机译：特发性快速眼动睡眠行为障碍患者的胆碱能药剂

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Background and purpose Cholinergic dysfunction appears to play a role in the cognitive impairment observed in Parkinson’s disease and dementia with Lewy bodies. The occurrence of cholinergic dysfunction in the early stages of these conditions, however, has not been investigated. The objective of this study was to investigate cholinergic function in patients with idiopathic rapid eye movement sleep behaviour disorder (iRBD), a disorder recognized to be an early stage of both Parkinson’s disease and dementia with Lewy bodies. Methods A total of 21 patients with polysomnography‐confirmed iRBD with no evidence of parkinsonism and cognitive impairment and 10 controls underwent positron emission tomography (PET) to assess brain acetylcholinesterase levels ( 11 C‐donepezil PET) and nigrostriatal dopaminergic function ( 18 F‐DOPA PET). Clinical examination included the Movement Disorder Society–Unified Parkinson’s Disease Rating Scale part III, Mini Mental State Examination and Montreal Cognitive Assessment. Results The 11 C‐donepezil PET was successfully performed in 17 patients with iRBD and nine controls. Compared with controls, patients with iRBD showed a mean 7.65% reduction in neocortical 11 C‐donepezil levels ( P ?=?0.005). Bilateral superior temporal cortex, occipital cortex, cingulate cortex and dorsolateral prefrontal cortex showed the most significant reductions at voxel level. Conclusion Reduced neocortical 11 C‐donepezil binding in our patients indicates cholinergic denervation and suggests that the projections from the nucleus basalis of Meynert, which supplies cholinergic innervation to the neocortex, are dysfunctional in iRBD. Longitudinal studies will clarify if these changes are predictive of future cognitive impairment in these patients.
机译：背景和目的胆碱能功能障碍似乎在帕金森病的疾病和痴呆症的认知障碍中发挥作用。然而，尚未研究这些条件的早期阶段的胆碱能功能障碍的发生。本研究的目的是探讨特发性快速眼动睡眠行为障碍（IRBD）患者的胆碱能功能，该疾病被认为是帕金森病和痴呆症的患者与雄鹿症的早期阶段。方法共21例多核桃木摄制患者确认的IRBD，没有帕金森主义和认知障碍的证据，10个对照接受正电子发射断层扫描（PET）的控制，以评估脑乙酰胆碱酯酶水平（11个C-ODEPEZIL PET）和NIGROSTRIAL多巴胺能功能（18个F-DOPA宠物）。临床检查包括运动障碍协会 - 统一帕金森病评级尺度第三部分，迷你精神状态考试和蒙特利尔认知评估。结果17例IRBD患者和九种对照成功进行11个C-ODEPEZIL PET。与对照组相比，IRBD患者显示了Neocortical 11 C-Deypezil水平的平均值7.65％（P？= 0.005）。双侧优越的时间皮质，枕骨皮质，刺刺肌冠状动脉和背侧前额叶皮质显示出体素水平最显着的减少。结论在患者中降低Neocortical 11 C-ODEPEZIL结合表明胆碱能证，表明Meynert的核心基底的突起，为Neocortex提供了胆碱能物质，在IRBD中存在功能障碍。纵向研究将澄清这些变化是否预测这些患者未来的认知障碍。

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