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首页> 外文期刊>European journal of neurology: the official journal of the European Federation of Neurological Societies >Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero in utero – the Norwegian Mother and Child Cohort Study
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Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero in utero – the Norwegian Mother and Child Cohort Study

机译：UTETO抗癫痫药物暴露后5岁和8岁儿童的语言损伤 - 挪威母亲和儿童队列研究

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Background and purpose The purpose was to examine the consequences of antiepileptic drug (AED) exposure during pregnancy on language abilities in children aged 5 and 8?years of mothers with epilepsy. Methods The study population included children of mothers with and without epilepsy enrolled in the Norwegian Mother and Child Cohort Study 1999–2008. Mothers prospectively provided information on epilepsy diagnosis, AED use during pregnancy and the child’s language abilities at age 5 and 8?years, in questionnaires with validated language screening tools. AED concentrations in gestation week 17–19 and in the umbilical cord were measured. Results The study population included 346 AED‐exposed and 388 AED‐unexposed children of mothers with epilepsy, and 113?674 children of mothers without epilepsy. Mothers of 117 and 121 AED‐exposed children responded to the questionnaires at age 5 and 8?years, respectively. For AED‐exposed children, the adjusted odds ratio for language impairment was 1.6 [confidence interval (CI) 1.1–2.5, P ?=?0.03] at age 5?years and 2.0 (CI 1.4–3.0, P ??0.001) at age 8?years, compared to children of mothers without epilepsy. Children exposed to carbamazepine monotherapy had a significantly increased risk of language impairment compared to control children at age 8?years (adjusted odds ratio 3.8, CI 1.6–9.0, P ?=?0.002). Higher maternal valproate concentrations correlated with language impairment at age 5?years. Periconceptional folic acid supplement use protected against AED‐associated language impairment. Conclusion Foetal AED exposure in utero is associated with an increased risk of language impairment in children aged 5 and 8?years of mothers with epilepsy. Periconceptional folic acid use had a protective effect on AED‐associated language impairment.
机译：背景和目的目的是审查抗癫痫药物（AED）暴露在妊娠期间的抗癫痫药物（AED）暴露于5岁和8岁的儿童的语言能力。癫痫患者的母亲。方法采用1999 - 2008年1999 - 2008年挪威母和儿童队列研究的母亲患有和没有癫痫的儿童。母亲正在前瞻性地提供有关癫痫诊断，怀孕期间的AED使用的信息，以及5岁和8岁的儿童语言能力，在具有验证语言筛选工具的问卷调查中。测量在妊娠周17-19和脐带中的AED浓度。结果研究人口包括346次曝光的母亲和388名母亲的母亲和388名患有癫痫的母亲，113岁？674个没有癫痫的母亲儿童。 117和121岁的母亲队的母亲在5岁和8岁时回应了调查问卷。对于暴露的儿童，语言损伤的调整赔率比为1.6 [置信区间（CI）1.1-2.5，p？=？0.03]，年龄和2.0（C1 1.4-3.0，P≤x≤0.001 ）在8岁？年，与没有癫痫的母亲的孩子相比。与4岁时的对照儿童相比，暴露于卡巴马嗪单疗法的儿童具有显着增加的语言损伤风险，而不是对照儿童（调整的赔率比3.8，CI 1.6-9.0，P？= 0.002）。较高的母戊酸酯浓度与5岁时与语言障碍相关的浓度？年份。 ericoncepional叶酸补充用途使用免受AED相关的语言障碍。结论UTERO胎儿AED暴露与5岁和8岁的儿童的语言损伤风险增加有关。癫痫患者的母亲多年。术术叶酸使用对AED相关的语言损伤具有保护作用。

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