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Skin blood flow influences cerebral oxygenation measured by near-infrared spectroscopy during dynamic exercise

机译:皮肤血流在动态运动期间通过近红外光谱测量的脑氧合

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摘要

Purpose: Near-infrared spectroscopy (NIRS) is widely used to investigate cerebral oxygenation and/or neural activation during physiological conditions such as exercise. However, NIRS-determined cerebral oxygenated hemoglobin (O2Hb) may not necessarily correspond to intracranial blood flow during dynamic exercise. To determine the selectivity of NIRS to assess cerebral oxygenation and neural activation during exercise, we examined the influence of changes in forehead skin blood flow (SkBFhead) on NIRS signals during dynamic exercise. Methods: In ten healthy men (age: 20 ± 1 years), middle cerebral artery blood flow velocity (MCA V mean, via transcranial Doppler ultrasonography), SkBFhead (via laser Doppler flowmetry), and cerebral O2Hb (via NIRS) were continuously measured. Each subject performed 60 % maximum heart rate moderate-intensity steady-state cycling exercise. To manipulate SkBFhead, facial cooling using a mist of cold water (~4 C) was applied for 3 min during steady-state cycling. Results: MCA V mean significantly increased during exercise and remained unchanged with facial cooling. O2Hb and SkBFhead were also significantly increased during exercise; however, both of these signals were lowered with facial cooling and returned to pre-cooling values with the removal of facial cooling. The changes in O2Hb correlated significantly with the relative percent changes in SkBFhead in each individual (r = 0.71-0.99). Conclusions: These findings suggest that during dynamic exercise NIRS-derived O2Hb signal can be influenced by thermoregulatory changes in SkBFhead and therefore, may not be completely reflective of cerebral oxygenation or neural activation.
机译:目的:近红外光谱(NIRS)被广泛用于研究生理条件(如运动)期间的脑氧合和/或神经激活。然而,NIRS确定的脑氧化血红蛋白(O 2 HB)可能不一定对应于动态运动期间的颅内血流。为了确定NIRS在运动期间评估脑氧合和神经激活的选择性,我们检查了在动态运动期间额头皮肤血流(SKBFHEAD)变化对NIRS信号的影响。方法:在十个健康男性(年龄:20±1年)中,中脑动脉血流速度(通过经颅多普勒超声检查,SKBFHEAD(通过激光多普勒流动性)和脑O2HB(VIA型均线)进行脑动脉血流速度(MCA V为MCA V表示) 。每个受试者进行60%的最高心率中等强度稳态循环运动。为了操纵SKBFHEAD,在稳态循环期间使用使用冷水雾(〜4℃)的面部冷却3分钟。结果:在运动期间MCA V意味着显着增加,面部冷却保持不变。运动期间O2HB和Skbfhead也显着增加;然而,两种信号都以面部冷却降低,并通过去除面部冷却而返回到预冷却值。 O2HB的变化显着,每个单独的SKBFHEAD的相对百分比变化(R = 0.71-0.99)。结论:这些发现表明,在动态运动期间,衍生的O 2 HB信号可以受SKBFHEAD的热调节变化的影响,因此,可能不完全反映脑氧合或神经活化。

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  • 作者单位

    Center for Biomedical Engineering Research Toyo University 2100 Kujirai Kawagoe Saitama 350-8585;

    Research Institute of Industrial Technology Toyo University 2100 Kujirai Kawagoe Saitama 350;

    Human Technology Research Institute National Institute of Advanced Industrial Science and;

    Human Technology Research Institute National Institute of Advanced Industrial Science and;

    Department of Medical Pharmacology and Physiology University of Missouri Columbia MO 65211;

    Center for Biomedical Engineering Research Toyo University 2100 Kujirai Kawagoe Saitama 350-8585;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 人体生理学;
  • 关键词

    Cerebral blood flow; Exercise; Laser Doppler flowmetry; Tissue oxygenation;

    机译:脑血流量;运动;激光多普勒流动性;组织氧合;

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