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首页> 外文期刊>European journal of clinical microbiology and infectious diseases: Official publication of the European Society of Clinical Microbiology >A rural worker infected with a bovine-prevalent genotype of Campylobacter fetus subsp. fetus supports zoonotic transmission and inconsistency of MLST and whole-genome typing
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A rural worker infected with a bovine-prevalent genotype of Campylobacter fetus subsp. fetus supports zoonotic transmission and inconsistency of MLST and whole-genome typing

机译：一种农村工人感染了训练术胎儿患者的牛普流基因型。 胎儿支持MLST和全基因组分别的动物区传播和不一致

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摘要

Whole-genome characterisation in clinical microbiology enables to detect trends in infection dynamics and disease transmission. Here, we report a case of bacteraemia due to Campylobacter fetus subsp. fetus in a rural worker under cancer treatment that was diagnosed with cellulitis; the patient was treated with antibiotics and recovered. The routine typing methods were not able to identify the microorganism causing the infection, so it was further analysed by molecular methods and whole-genome sequencing. The multi-locus sequence typing (MLST) revealed the presence of the bovine-associated ST-4 genotype. Whole-genome comparisons with other C. fetus strains revealed an inconsistent phylogenetic position based on the core genome, discordant with previous ST-4 strains. To the best of our knowledge, this is the first C. fetus subsp. fetus carrying the ST-4 isolated from humans and represents a probable case of zoonotic transmission from cattle.
机译：临床微生物学中的全基因组特征能够检测感染动力学和疾病传播的趋势。 在这里，我们报告了由于训练率患者因弯曲杆菌因子而导致的菌株。 在癌症治疗下患有蜂窝织炎的癌症治疗的胎儿; 患者用抗生素治疗并回收。 常规键入方法无法识别导致感染的微生物，因此通过分子方法和全基因组测序进一步分析。 多基因座序列键入（MLST）揭示了牛相关的ST-4基因型的存在。 与其他C.胎儿菌株的全基因组比较揭示了基于核心基因组的不一致的系统发育位置，与先前的ST-4菌株不和谐。 据我们所知，这是第一个C.胎儿亚数据。 胎儿携带ST-4与人类隔离，代表了牛群中的动物传播的可能情况。

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