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首页> 外文期刊>European journal of cancer care >Body weight changes after adjuvant chemotherapy of patients with breast cancer: results of a Mexican cohort study
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Body weight changes after adjuvant chemotherapy of patients with breast cancer: results of a Mexican cohort study

机译：乳腺癌患者辅助化疗后的体重变化：墨西哥队列研究结果

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摘要

Weight gain is observed in breast cancer patients receiving chemotherapy and is a well-known complication. Several factors that contributing to weight gain have been identified. However, there is a lack of information about factors associated with weight changes following adjuvant chemotherapy. A retrospective cohort of 200 pre- and post-menopausal Mexican patients treated for breast cancer was made. Anthropometric variables were measured before/after treatment. Biomarkers, cellular differentiation and chemotherapy were similar between groups. Weight gain occurred in 85.6% of pre-menopausal and 72.6% of post-menopausal women (p =.03). At the end of chemotherapy, weight and body mass index (BMI) did not differ significantly between pre-menopausal (69.3 +/- 12.6 kg; 26.6 +/- 4.8 kg/m(2)) and post-menopausal women (69.5 +/- 10.9 kg; 27.3 +/- 4.4 kg/m(2)) (p = .91 and 0.34). Dexamethasone doses were higher in pre-menopausal (85.7 +/- 39.1 g) than post-menopausal patients (79.2 +/- 22.5 g; p = .13). Weight loss was observed in 9.2% of pre-menopausal and 20.2% of post-menopausal patients (p = .04). A multivariate analysis revealed that age (OR = 2.7; 95% CI = 1.26-5.79; p = .01), menopausal status (OR = 2.29; 95% CI = 1.09-4.80; p =.03), dexamethasone dosage (OR = 2.1; 95% CI = 1.04-4.23; p = .03) and daily caloric intake (OR = 2.3; 95% CI = 1.12-5.10; p =.02) were independent variables that inducted weight gain. Pre-and post-menopausal women gained weight, but more pre-menopausal patients showed gain.
机译：在接受化疗的乳腺癌患者中观察到体重增加，并且是一个众所周知的并发症。已经确定了有助于体重增加的几个因素。然而，辅助化疗后，缺乏有关与重量变化相关的因素的信息。制造了对乳腺癌治疗的200个预期和绝经后墨西哥患者的追溯队列。在处理之前/后测量人体测量变量。群体之间的生物标志物，细胞分化和化疗之间相似。体重增加发生在绝经前的85.6％，72.6％的绝经后妇女（P = .03）。在化疗结束时，预体内（69.3 +/- 12.6kg）之间的体重和体重指数（BMI）没有显着差异（69.3 +/- 12.6公斤; 26.6 +/- 4.8 kg / m（2））和绝经后妇女（69.5 + / - 10.9千克; 27.3 +/- 4.4 kg / m（2））（p = .91和0.34）。美女前甲基塞塞（85.7 +/- 39.1g）较高比绝经后患者更高（79.2 +/- 22.5g; p = .13）。在9.2％的预期前血尿病和20.2％的绝经后患者中观察到体重减轻（P = .04）。多变量分析显示年龄（或= 2.7; 95％CI = 1.26-5.79; p = .01），更年期状态（或= 2.29; 95％CI = 1.09-4.80; p = .03），地塞米松剂量（或= 2.1; 95％CI = 1.04-4.23; p = .03）和每日热量摄入（或= 2.3; 95％CI = 1.12-5.10; p = .02）是电感重量增益的独立变量。预先和绝经后妇女的重量，但更多的前列腺前期患者表现出增益。

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