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The value of biomarkers in bone metastasis

机译:骨转移中的生物标志物的价值

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The worst complication of cancer is represented by its spread to distant sites. In particular, bone provides a fertile soil for several cancer types, especially those derived from breast, prostate and lung tumours. Despite the progress in diagnostic and therapeutic strategies, bone metastases ( BM ) still impact on quality of life and overall survival, making it necessary to identify the “high‐risk” patients at an earlier stage. Since BM affect physiological bone turnover, measurement of bone turnover markers ( BTM ) has been widely investigated for diagnostic and prognostic purposes, as well as to support the development of anti‐cancer drugs. Furthermore, biomarkers are still under intensive investigation for their potential BM predictive role. The review summarises the current knowledge on BM development and the most recent advances in biomarker research, focusing on breast, prostate and lung malignancies.
机译:癌症的最糟糕并发症是由其扩散到远处部位的表现。 特别是,骨骼为几种癌症类型提供了一种肥沃的土壤,尤其是源自乳腺,前列腺和肺肿瘤的土壤。 尽管诊断和治疗策略进展,骨转移(BM)仍然影响生活质量和整体生存,因此有必要在早期阶段识别“高风险”患者。 由于BM影响生理骨质周转,因此骨质周转标记(BTM)的测量已被广泛研究诊断和预后目的,以及支持抗癌药物的发展。 此外,生物标志物仍处于密集调查,以潜在的BM预测作用。 该审查总结了目前对BM发展的知识以及生物标志物研究中最新进展,重点是乳腺,前列腺和肺部恶性肿瘤。

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