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首页> 外文期刊>European journal of cancer care >Health resource utilisation associated with skeletal‐related events in patients with bone metastases secondary to solid tumours: regional comparisons in an observational study
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Health resource utilisation associated with skeletal‐related events in patients with bone metastases secondary to solid tumours: regional comparisons in an observational study

机译：与实体瘤中的骨转移患者骨转移患者骨骼相关事件相关的健康资源利用：在观察研究中的区域比较

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Skeletal‐related events (SREs) including spinal cord compression, pathologic fracture, and radiation or surgery to bone, occur frequently due to bone metastases in advanced cancer. This analysis of a multicentre, observational study was designed to describe cross‐regional differences in health resource utilisation (HRU) of SREs in Western Europe and the US. Patients with bone metastases due to breast, lung or prostate cancer, or multiple myeloma who had experienced a SRE within the past 97?days were enrolled. Investigators recorded HRU associated with SREs, including hospitalisation and length of stay (LOS), outpatient visits, procedures and bisphosphonate use. This subanalysis includes 668 patients with solid tumours (US, n ?=?190 with 354 SREs; EU, n ?=?478 with 893 SREs). The rate of SREs associated with hospitalisation(s) was higher in the EU vs. the US (30% vs. 15%, P ??0.001) and LOS was longer in the EU [mean (SD) days/SRE: 19.87 (17.31) vs. 10.61 (9.39)]. However, the US was associated with higher rate of SREs with outpatient visits than the EU (88% vs. 74%, P ??0.0001) and more procedures [mean (SD)/SRE: 11.26 (7.94) vs. 6.91 (6.48)]. Bisphosphonates were less often used in the EU (65% vs. 76% of US, P ?=?0.0033). In patients experiencing SREs due to bone metastases, HRU patterns reflect regional diversity with a substantial burden in both regions.
机译：骨骼相关事件（SRES）包括脊髓压缩，病理骨折和辐射或骨骼的辐射或手术，经常由于晚期癌症中的骨转移而发生。这种对多期形的观察研究分析旨在描述西欧和美国康复健康资源利用（HRU）的跨区域差异。由于乳腺癌，肺或前列腺癌，或在过去97年内经历了SRE的多发性骨髓瘤患者入学。调查人员记录了与SRE相关的HRU，包括住院治疗和逗留时间（LOS），门诊访问，程序和双膦酸盐使用。该细分分析包括668名固体肿瘤患者（美国，N？= 190，带有354 SRES;欧盟，N？= 478，893 SRES）。与住院治疗相关的SRE率在EU与美国（30％vs.15％，p≤0.<0.001）和欧盟更长的时间[平均值（SD）天/ SRE： 19.87（17.31）与10.61（9.39）]。然而，美国与远诊速度高于欧盟（88％vs.74％，p≤0.0001）和更多程序[平均（SD）/ SRE：11.26（7.94）与6.91 （6.48）]。欧盟的双膦酸盐较少使用（US的65％vs.76％，p？= 0.0033）。在由于骨转移引起的患者中，患有SRE的患者，HRU模式反映了各个地区的大量负担的区域多样性。

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