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首页> 外文期刊>European journal of cancer prevention: The official journal of the European Cancer Prevention Organisation (ECP) >Exploring the long noncoding RNAs-based biomarkers and pathogenesis of malignant transformation from dysplasia to oral squamous cell carcinoma by bioinformatics method
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Exploring the long noncoding RNAs-based biomarkers and pathogenesis of malignant transformation from dysplasia to oral squamous cell carcinoma by bioinformatics method

机译：通过生物信息化方法探讨缺乏发育血糖对口腔鳞状细胞癌恶性转化的长度非划分的基于RNA的生物标志物及其发病机制

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Long noncoding RNAs (lncRNAs) play an important role in many biological processes and carcinogenesis. We aimed to explore lncRNA-based pathogenesis, diagnostic biomarkers, and predictive factors of malignant transformation from dysplasia to oral squamous cell carcinoma (OSCC). Microarray data of GSE30784 consisting of 167 OSCC, 17 dysplasia, and 45 normal oral tissues were downloaded from the GEO database. The differentially expressed genes (DEGs) and lncRNAs between the three samples were identified using R, followed by lncRNA-mRNA coexpression and coregulation network analysis for the prediction of lncRNA target genes. Gene Ontology and Kyoto encydopedia of gene and genomes pathway analysis were performed to further characterize potential interactions. A total of 4462 DEGs and 76 differentially expressed lncRNAs were screened between the three groups, and 200 DEGs and only double homeobox A pseudogene 10 ( DUXAP10 ) were screened among the three groups. A total of 1662 interactions of 46 lncRNAs and their coexpressed target genes were predicted, and 38 pairs of lncRNA-lncRNA coregulated 843 target genes. The coregulated target genes significantly enriched in antigen adaptive immune response, activation of phagocytosis receptor signaling, mast granule NF-κB inflammation, etc. Overall, lncRNAs were differentially expressed in OSCC and dysplasia. The target genes might play an important role in the carcinogenesis and development of OSCC. These results improve our understanding regarding the lncRNA-based pathogenesis and identify some potential targets for early diagnosis of malignant transformation from dysplasia to OSCC.
机译：长度非编码RNA（LNCRNA）在许多生物过程和致癌中起着重要作用。我们的旨在探索基于LNCRNA的发病机制，诊断生物标志物和来自发育不良转化的恶性转化对口腔鳞状细胞癌（OSCC）的预测因素。 GSE30784的微阵列数据由167个OSCC，17个发育性和45个正常口腔组织从Geo数据库下载。使用R鉴定三个样品之间的差异表达的基因（DEG）和LNCRNA，然后鉴定出LNCRNA-mRNA共表达和CoreGulation网络分析，用于预测LNCRNA靶基因。基因本体和京都基因组成型途径分析以进一步表征潜在的相互作用。在三组之间筛选了总共4462℃和76个差异表达的LNCRNA，并且在三组中筛选了200℃，只有两次，只有双Homeobox伪霉素10（Duxap10）。预计总共1662个相互作用和它们的共置靶基因，38对LNCRNA-LNCRNA Coreguted 843靶基因。在抗原适应性免疫应答中显着富集的重组靶基因，吞噬症受体信号传导的激活，粪便颗粒NF-κB炎症等总体上，LNCRNA在OSCC和Dysplasia中表达差异。靶基因可能在OSCC的致癌作用中发挥重要作用。这些结果改善了对LNCRNA的发病机制的理解，并确定了一些潜在的目的，用于早期诊断发育不良转移到OSCC的恶性转化。

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