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首页> 外文期刊>European journal of pediatrics >Helicobacter pylori infection, serum pepsinogens, and pediatric abdominal pain: a pilot study
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Helicobacter pylori infection, serum pepsinogens, and pediatric abdominal pain: a pilot study

机译：幽门螺杆菌感染，血清胃肠杆菌和小儿腹痛：试验研究

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摘要

The significance of Helicobacter pylori (H. pylori) infection in pediatric abdominal pain remains poorly recognized. We examined associations of H. pylori infection and serum pepsinogens (PGs), as non-invasive markers of gastritis, with pediatric abdominal pain. A case-control study was conducted among 99 children aged 5-17 years admitted to one hospital for abdominal pain (cases) without an apparent organic reason. Using enzyme-linked immunosorbent assays, sera were tested and compared with 179 controls for anti-H. pylori immunoglobulin G (IgG) antibodies and PGI and PGII levels. Multivariable analysis was performed to adjust for potential confounders. H. pylori IgG sero-positivity was 34.3 and 36.3% in cases and controls, respectively, P = 0.7. H. pylori-infected children had higher median PGI and PGII levels and a lower PGI/PGII ratio than uninfected children. Cases infected with H. pylori had a higher median PGII level (P < 0.001) and lower PGI/PGII ratio (P = 0.036) than controls infected with H. pylori. The percentage of cases with PGII >= 7.5 mu g/L, as indication for antral inflammation, was higher than in controls: 58.6 versus 44.7%, P = 0.027. Children with PGII levels >= 7.5 mu g/L had increased risk for abdominal pain: adjusted prevalence ratio 1.73 [95% confidence intervals 1.02, 2.93], P = 0.039.
机译：幽门螺杆菌（H.Pylori）感染在儿科腹痛中的意义仍然不知识。我们检查了H. Pylori感染和血清肽（PGS）的关联，作为胃炎的非侵入性标志物，具有儿科腹痛。在没有表观有机原因的情况下，在5-17岁的5-17岁儿童中进行了一个病例对照研究，没有表观有机原因。使用酶联免疫吸附试验，测试血清并与179个抗H对照进行比较。 Pylori免疫球蛋白G（IgG）抗体和PGI和PGII水平。进行多变量分析以调整潜在的混淆。 H. Pylori IgG血清阳性分别为34.3和36.3％，分别对照，P = 0.7。 H. Pylori感染的儿童具有较高的中位数PGI和PGII水平，PGI / PGII比率低于未感染的儿童。感染H. Pylori的病例具有较高的中值PGII水平（P <0.001）和低于Pycori的对照（P = 0.036）的PGI / PGII比率（P = 0.036）。 PGII> =7.5μg/ L的病例百分比，作为嗜睡炎症的指示，高于对照：58.6与44.7％，p = 0.027。具有PGII水平的儿童> =7.5μg/升腹痛风险增加：调节患病率比1.73 [95％置信区间1.02,2.93]，P = 0.039。

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