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首页> 外文期刊>European journal of pediatrics >Effect of caffeine on respiratory muscle strength and lung function in prematurely born, ventilated infants.
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Effect of caffeine on respiratory muscle strength and lung function in prematurely born, ventilated infants.

机译：咖啡因对过早出生，通风婴儿呼吸肌强度和肺功能的影响。

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The aims of this study were to determine whether caffeine administration increased respiratory muscle function and if this was associated with lung function improvement in prematurely born infants being weaned from mechanical ventilation. Respiratory muscle function was assessed by measurement of the maximum pressures generated during occlusions at end inspiration (Pemax) and end expiration (Pimax) and lung function by measurement of lung volume (functional residual capacity (FRC)) and respiratory system compliance (CRS) and resistance (RRS) in 18 infants with a median gestational age of 28 (range 24-36) weeks. Measurements were made immediately prior to caffeine administration (baseline) and 6 h later. Six hours after caffeine administration compared to baseline, the median Pemax (p = 0.017), Pimax (p = 0.004), FRC (p < 0.001), CRS (p = 0.002) and RRS (p = 0.004) had significantly improved. Our results suggest that caffeine administration facilitates weaning of prematurely born infants from mechanical ventilation by improving respiratory muscle strength.
机译：本研究的目的是确定咖啡因给药是否增加呼吸肌功能，如果这与从机械通气断奶断奶的过早出生的婴儿的肺功能改善有关。通过测量在最终吸气（PEMAX）和肺部末期（PIMAX）和肺部函数（功能残留能力（FRC））和呼吸系统依从性（CRS）和呼吸系统和肺部）和肺功能期间产生的最大压力评估呼吸肌功能18个婴儿的抗性（RRS），中位于28（24-36）周的妊娠期28岁的婴儿。在咖啡因施用（基线）和6小时之前立即进行测量。咖啡因管理后六小时与基线相比，中值Pemax（P = 0.017），PiMax（P = 0.004），FrC（P <0.001），Crs（P = 0.002）和RRS（P = 0.004）显着提高。我们的研究结果表明，通过改善呼吸肌力量，咖啡因管理促进了从机械通气的过早出生的婴儿断奶。

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