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首页> 外文期刊>European journal of gynaecological oncology >Childhood malignant ovarian germ cell tumors: a single institution experience
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Childhood malignant ovarian germ cell tumors: a single institution experience

机译：儿童恶性卵巢胚芽细胞肿瘤：单一机构经验

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摘要

Purpose of investigation: This study aimed to analyze the clinical characteristics and outcome of children with malignant ovarian germ cell tumors (MOGCTs), and to investigate the therapeutic strategy. Materials and Methods: All patients with MOGCTs in a single institution during the period January 2001 to December 2012 were analyzed according to the characteristics of patients, treatment, and outcome. Results: Eight-nine patients with MOGCTs had a median age 9.5 (range, 0-15) years. Abdominal pain and abdominal distension were the most frequent clinical presentations. Elevated APP was observed in 78 cases (87.6%). Eighty-seven patients received surgery plus chemotherapy. The surgical procedures consisted of salpingo-oophorectomy plus omentectomy (n=39), salpingo-oophorectomy (n=39), and oophorectomy (n=11). Five patients died: three from disease, one from leukopenic sepsis, and one from disseminated varicella. The overall five-year survival rate was 95.5% for all patients, 100% for Stage I, 96.2% for Stage II, 95% for Stage III, 91.7% for Stage IV, and 71.4% for relapse patients, respectively. Forty-one out of 49 patients in puberty or reproductive age had regular menstrual cycles. Six patients had menostaxis, and two patients required psychological input during the follow up period. Two patients delivered healthy infants without congenital defects. Conclusion: The prognosis of malignant ovarian germ cell tumor is favorable. Surgery combined with platinum-based chemotherapy can improve curative efficacy and survival. Further investigation of novel and high-dose chemotherapic regimens is needed for the patients with relapsed tumors. Sex hormone replacement therapy is not necessary for most patients receiving fertility-preserving surgery.
机译：调查目的：本研究旨在分析恶性卵巢胚芽细胞肿瘤（MOGCTS）的临床特征和结果，并调查治疗策略。材料和方法：根据患者，治疗和结果的特征分析了2001年1月至2012年12月期间单一机构中的所有床上的患者。结果：八九患者的MOGCTS有中位数9.5（范围，0-15）年。腹痛和腹胀是最常见的临床介绍。在78例（87.6％）中观察到升高的应用程序。八十七名患者接受手术加上化疗。外科手术由Salpingo-Oophorectomy Plus概念（n = 39）组成，Salpingo-oophorectomy（n = 39）和oophorectomy（n = 11）组成。五名患者死亡：来自疾病的三个，一个来自白血病败血症，其中一个来自散发的水痘。所有患者的总体五年生存率为95.5％，阶段I的100％，阶段II的96.2％，阶段III的95％，阶段阶段91.7％，复发患者分别为91.7％，分娩患者71.4％。 49名患者中的49名患者中的四十一岁或生殖年龄有规律的月经周期。六名患者有肠外肠果，两名患者在后续期间需要心理投入。两名患者提供健康婴儿，没有先天性缺陷。结论：恶性卵巢胚芽细胞肿瘤的预后是有利的。手术结合铂金疗法可以提高疗效和生存。对复发肿瘤的患者需要进一步调查新型和高剂量化疗方案。大多数患者没有必要对接受生育能力的手术的患者进行性激素替代疗法。

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  • 作者

    Yang C.; Tan J.; Li C. C.; Zhang J.; Kong X. R.; Zhao Z.; Deng X.; Peng L.; Wang S.;

  • 作者单位

    Chongqing Med Univ Childrens Hosp Minist Educ Key Lab Child Dev &

    Disorders Chongqing Peoples;

    Chongqing Med Univ Childrens Hosp Clin Dept Lijia Campus Chongqing Peoples R China;

    Chongqing Med Univ Childrens Hosp Minist Educ Key Lab Child Dev &

    Disorders Chongqing Peoples;

    Chongqing Med Univ Childrens Hosp Minist Educ Key Lab Child Dev &

    Disorders Chongqing Peoples;

    Chongqing Med Univ Childrens Hosp Minist Educ Key Lab Child Dev &

    Disorders Chongqing Peoples;

    Chongqing Med Univ Childrens Hosp Minist Educ Key Lab Child Dev &

    Disorders Chongqing Peoples;

    Chongqing Med Univ Childrens Hosp Minist Educ Key Lab Child Dev &

    Disorders Chongqing Peoples;

    Chongqing Med Univ Childrens Hosp Minist Educ Key Lab Child Dev &

    Disorders Chongqing Peoples;

    Chongqing Med Univ Childrens Hosp Minist Educ Key Lab Child Dev &

    Disorders Chongqing Peoples;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 妇产科学;
  • 关键词

    Pediatrics; Malignant ovarian germ cell tumor (MOGCT); Chemotherapy; Survival rate;

    机译：儿科;恶性卵巢胚芽细胞肿瘤（MOGCT）;化疗;生存率;

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