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首页> 外文期刊>European journal of gynaecological oncology >Diffusion magnetic resonance in cervical carcinoma: the role of apparent diffusion coefficient in the evaluation of treatment response
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Diffusion magnetic resonance in cervical carcinoma: the role of apparent diffusion coefficient in the evaluation of treatment response

机译:扩散磁共振在宫颈癌中:表观扩散系数在治疗反应评估中的作用

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Purpose: The aim of the study was to determinate the role of apparent diffusion coefficient ADC) in order to find cut-off values in the evaluation of treatment response. Materials and Methods: A retrospective study was undertaken on MRIs of three groups of patients: 17 with histologically proven cervical carcinoma group 1), 16 with complete regression after chemo-radiotherapy group 2), and 46 without pathology group 3). Three non-overlapping ROIs were manually drawn through neoplastic tissue and normal cervical areas,. regions of interest ROIs) median values were calculated. Student t-test, ANOVA test, receiver operating characteristic ROC) curves, and Youden Index were performed. Results: The most important data was obtained by ROC curve and Youden index calculated between free from disease merged group groups 2+ 3) and ill patients group 1): 1.18 x10(-3)mm(2)/s 94% sensibility,100% specificity), was the cut-off ADC value. Values below this cut-off could be considered as recurrent pathology with high accuracy. Conclusions: ADC represents a fundamental quantitative tool in follow-up of chemo-radiant treatment response in advanced cervical carcinoma.
机译:目的:该研究的目的是确定表观扩散系数ADC的作用)为了发现治疗反应评估中的截止值。材料和方法:对三组患者的MRIS进行了回顾性研究:17,组织学证实宫颈癌组1),16组化学放射疗法组2)后完全回归,46组没有病理组3)。通过肿瘤组织和正常的宫颈区域手动吸取三个非重叠的ROI。利益区域ROIS)计算中值值。进行学生T检验,ANOVA测试,接收器操作特征ROC)曲线和YEN指数。结果:通过疾病合并组2+ 3)和ILL患者组的ROC曲线和YOYDEN指数获得的最重要数据是1):1.18 X10(-3)mm(2)/ s 94%的敏感性,100 %特异性)是截止ADC值。低于该截止的值可以被视为具有高精度的反复性病理学。结论:ADC代表了晚期宫颈癌的化学辐射治疗反应随访的基本定量工具。

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