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首页> 外文期刊>European journal of gynaecological oncology >Low-dose range of pelvic irradiation leads to acute hematological toxicity in early-stage cervical cancer with intermediate risk factors by postoperative intensity-modulated radiotherapy
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Low-dose range of pelvic irradiation leads to acute hematological toxicity in early-stage cervical cancer with intermediate risk factors by postoperative intensity-modulated radiotherapy

机译：低剂量范围的盆腔照射导致早期宫颈癌的急性血液毒性，术后强度调节放疗的中间危险因素

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摘要

Purpose: To analyze the correlation between acute hematological toxicity (HT) due to the irradiation volume to the pelvis low-dose region (PLDR) from postoperative intensity-modulated radiotherapy (IMRT) for intennediate-risk early-stage cervical cancer. Materials and Methods: The medical records of 125 patients with intermediate-risk IA-IIA cervical cancer treated with postoperative radiotherapy were retrospectively reviewed. The nadir of leukocyte, neutrophil, lymphocyte, erythrocyte, hemoglobin, and platelet counts were collected from the beginning of radiotherapy to three months after radiotherapy.The volume of pelvic bone marrow >= 5 Gy, 10 Gy, and 20 Gy (V5, V10, and V20) of the PLDR in IMRT were obtained using a dose volume histogram. Results: V10 and V20 were independent factors of grade >= 2 leukopenia and neutropenia. V10 was an independent risk factor of grade >= 3 lymphopenia. V10 > 86%, V20 > 73%, V10 > 88%, and V20 > 73% can cause grade >= 2 leukopenia and neutropenia. A V10 of > 80% is more likely to occur than grade 3 lymphopenia. Preoperative neoadjuvant chemotherapy will aggravate HT after pelvic radiotherapy, especially leukocytes. Conclusion: In patients with early cervical cancer with intermediate risk factors by postoperative IMRT, the volume of V10 and V20 in the low-dose pelvic region should be limited to reduce HT.
机译：目的：分析急性血液毒性（HT）与骨盆低剂量区域（PLDR）的相关性来自术后强度调制的放疗（IMRT）的急性血液毒性（PLDR）的相关性。材料与方法：回顾性审查了用术后放疗治疗的125例中间风险IA-IIA宫颈癌的病历。从放疗开始到放疗后三个月的白细胞，嗜中性粒细胞，淋巴细胞，红细胞，血红蛋白和血小板计数。骨盆骨髓的体积> = 5 GY，10 GY和20 GY（V5，V10使用剂量体积直方图获得IMRT中PLDR的V20）。结果：V10和V20是级别的级别> = 2个白细胞减少症和中性粒细胞率。 V10是级别的危险因素，= 3次淋巴细胞增长。 V10> 86％，V20> 73％，V10> 88％，V20> 73％可引发级别> = 2次白细胞减少症和中性粒细胞病。 V10的> 80％的v10比3年级淋巴细胞增长更容易发生。术前Neoadjuvant化疗将在盆腔放射疗法，尤其是白细胞后加重HT。结论：术后IMRT患有中期宫颈癌的患者，低剂量盆腔区域V10和V20的体积应限制为减少HT。

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