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首页> 外文期刊>European Journal of Haematology >Saving whom? The ethical challenges of harvesting tissue from savior siblings
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Saving whom? The ethical challenges of harvesting tissue from savior siblings

机译：保存谁？ 从救主兄弟姐妹收获组织的道德挑战

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Abstract Purpose of the study To discuss the ethical challenges for the therapeutic team when dealing with a young savior sibling as a potential tissue donor. Basic procedures Savior siblings are children that are created to serve a sibling as a donor of umbilical cord blood, bone marrow, or peripheral blood from which hematopoietic stem cells are derived. These cells are used for hematopoietic stem cell therapy, which is the only curative treatment for certain hemoglobinopathies. We used a case including a 19‐year‐old thalassemia patient and his two and a half year old sister from our practice as ethics consultants. Our methodological basis is the principlism approach by Beauchamp and Childress, consisting of four principles: autonomy, non‐maleficence, beneficence, and justice. Main findings We found that the main conflict arises between the autonomy of the savior sibling as well as the non‐maleficence regarding her and the beneficence of the thalassemia patient. Principal conclusions Decision‐making is complex when decisions within the family are concerned, especially when non‐competent young children are involved. The therapeutic team does not only have to recognize the principal vulnerability of children but also the different scales of vulnerability depending on their age.
机译：摘要研究目的，讨论治疗团队的伦理挑战，作为潜在的组织供体。基本程序救世主兄弟姐妹是创造的儿童，以作为脐带血，骨髓或造血干细胞的脐血血液，骨髓或外周血的捐赠者。这些细胞用于造血干细胞疗法，这是某些血吸虫病的唯一治疗方法。我们使用了一个案例，其中包括19岁的Thalassemia患者和他的两岁和半年的妹妹，从我们的练习中作为道德顾问。我们的方法论基础是Beauchamp和Childress的原则方法，包括四个原则：自治，非恶意，福利和正义。主要发现我们发现，救世主兄弟姐妹的自主权以及对她的非恶意和脑血症患者的益友之间的主要冲突。当家庭内部涉及的决策时，主要结论决定是复杂的，特别是当涉及非合格的幼儿时。治疗团队不仅必须认识到儿童的主要脆弱性，而且根据其年龄的年龄，也是不同的脆弱程度。

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