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首页> 外文期刊>Advances in enzyme regulation >Causes and consequences of acidic pH in tumors: a magnetic resonance study.
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Causes and consequences of acidic pH in tumors: a magnetic resonance study.

机译：酸性pH值在肿瘤中的起因和后果：磁共振研究。

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A consequence of metabolism in any tissue is the formation of hydrogen ions, which are actively transported out of the cell. However, although most solid tumors maintain their intracellular pH (pHi) within a narrow range to provide a favorable environment for various intracellular activities, their extracellular pH (pHe) is on average about 0.2 pH units more acid. It is important to understand the relationship between tumor metabolism and pH, and how it differs from that of normal tissue and to ask the question: How does an understanding of pH and tumor metabolism affect strategies for therapeutic approaches? Although, in vitro, isolated cell experiments have shown positive correlations between pHi and pHe the relationship is complex and somewhat dependent on experimental conditions. Measurement of pHi in solid tumors by non-invasive Magnetic Resonance Spectroscopy (MRS) has been possible for some time now and recently several specific markers for measuring pHe have become available. As a result we have been able to study the relationship between pHi and pHe in vivo in several different solid tumor types. In only one tumor type (HT29 xenografts) was there a significant correlation between pHi and pHe; in 3 other tumor types (RIF-1 in mice, GH3 prolactinomas and H9618a in rats) there was no correlation. A significant correlation between pHi and NTP/Pi ratios was seen across all tumor types. Theoretical considerations of causes of tumor acidity, hypotheses to explain extracellular acidity and the possibility that low pHe might be an intrinsic feature of the tumor phenotype and not merely the consequence of metabolic activity have been discussed. In addition the consquences for concepts of treatment based on pH are considered.
机译：任何组织中新陈代谢的结果是形成氢离子，这些氢离子被主动转运出细胞。然而，尽管大多数实体瘤将它们的细胞内pH（pHi）维持在窄范围内以为各种细胞内活性提供有利的环境，但是它们的细胞外pH（pHe）平均多约0.2个pH单位的酸。重要的是要了解肿瘤代谢和pH之间的关系，以及它与正常组织之间的区别，并提出一个问题：对pH和肿瘤代谢的了解如何影响治疗方法的策略？尽管在体外，离体细胞实验表明pHi和pHe之间呈正相关，但这种关系很复杂，并且在一定程度上取决于实验条件。通过无创磁共振波谱（MRS）测量实体瘤中的pHi已有一段时间，并且最近有几种用于测量pHe的特定标记物可用。结果，我们已经能够在几种不同的实体瘤类型中体内研究pHi和pHe之间的关系。在仅一种肿瘤类型（HT29异种移植物）中，pHi和pHe之间存在显着相关性。在其他3种肿瘤类型（小鼠中的RIF-1，大鼠中的GH3泌乳素瘤和H9618a）之间没有相关性。在所有类型的肿瘤中，pHi和NTP / Pi比值之间均存在显着相关性。讨论了肿瘤酸性的原因的理论考虑，解释细胞外酸性的假设以及低pHe可能是肿瘤表型的固有特征，而不仅仅是代谢活性的结果的可能性。另外，考虑了基于pH的处理概念的结果。

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