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首页> 外文期刊>Advances in enzyme regulation >Regulation of homocysteine metabolism.
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Regulation of homocysteine metabolism.

机译：同型半胱氨酸代谢的调节。

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摘要

We have used a combination of in vivo and in vitro techniques to measure factors regulating homocysteine metabolism and the plasma concentration of this atherogenic amino acid. The germane findings include: 1. Homocysteine metabolism in rat kidney proceeds predominantly through the transsulfuration pathway, whose enzymes are enriched within the proximal cells of kidney tubules. Furthermore, the rat kidney possesses significant reserve capacity to handle both acute and chronic elevations in plasma homocysteine concentrations. 2. Plasma homocysteine concentrations are lower in diabetic rats. Insulin administration corrects this perturbation. Therefore, insulin and/or one of its counter-regulatory hormones affects homocysteine metabolism, possibly through an increased flux in the hepatic transsulfuration pathway. In support of these data, glucagon administration to rats produced similar results. Further support was provided by studies with isolated rat hepatocytes, from which homocysteine export was reduced when incubated in the presence of glucagon.
机译：我们使用体内和体外技术的组合来测量调节同型半胱氨酸代谢和致动脉粥样硬化氨基酸的血浆浓度的因素。相关的发现包括：1.大鼠肾脏中的同型半胱氨酸代谢主要通过转硫途径进行，其酶富集在肾小管的近端细胞内。此外，大鼠肾脏具有显着的储备能力来应对血浆高半胱氨酸浓度的急性和慢性升高。 2.糖尿病大鼠血浆同型半胱氨酸浓度较低。胰岛素管理可以纠正这种干扰。因此，胰岛素和/或其反调节激素之一可能通过肝转硫途径中通量的增加影响同型半胱氨酸代谢。为了支持这些数据，向大鼠施用胰高血糖素产生了相似的结果。对分离的大鼠肝细胞的研究提供了进一步的支持，当在胰高血糖素存在下孵育时，同型半胱氨酸的输出减少。

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